Search Results

Overview

Uniprot IDQ9NTK5
Protein NameObg-like ATPase 1
Gene NameOLA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
333 KAPQAAGKIHTDFEK
394 FNTPQQPKKK*****
396 TPQQPKKK*******
5 ***MPPKKGGDGIKP
83 QYHKPASKIPAFLNV

Function

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP

Protein Sequence

10 MPPKKGGDGI 20 KPPPIIGRFG 30 TSLKIGIVGL 40 PNVGKSTFFN 50 VLTNSQASAE 60 NFPFCTIDPN 70 ESRVPVPDER 80 FDFLCQYHKP 90 ASKIPAFLNV 100 VDIAGLVKGA 110 HNGQGLGNAF 120 LSHISACDGI 130 FHLTRAFEDD 140 DITHVEGSVD 150 PIRDIEIIHE 160 ELQLKDEEMI 170 GPIIDKLEKV 180 AVRGGDKKLK 190 PEYDIMCKVK 200 SWVIDQKKPV 210 RFYHDWNDKE 220 IEVLNKHLFL 230 TSKPMVYLVN 240 LSEKDYIRKK 250 NKWLIKIKEW 260 VDKYDPGALV 270 IPFSGALELK 280 LQELSAEERQ 290 KYLEANMTQS 300 ALPKIIKAGF 310 AALQLEYFFT 320 AGPDEVRAWT 330 IRKGTKAPQA 340 AGKIHTDFEK 350 GFIMAEVMKY 360 EDFKEEGSEN 370 AVKAAGKYRQ 380 QGRNYIVEDG 390 DIIFFKFNTP QQPKKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0016020 membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0031093 platelet alpha granule lumen
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0043023 ribosomal large subunit binding
Biological Process GO:0046034 ATP metabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.