Overview
| Uniprot ID | Q9NTN3 |
|---|
| Protein Name | Nucleotide sugar transporter SLC35D1 |
|---|
| Gene Name | SLC35D1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 19 |
VKGEAPAKSSTLRDE |
Function
Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar (PubMed:16965264, PubMed:17599910, PubMed:31423530). Transports various UDP-sugars including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides (PubMed:11322953, PubMed:16965264, PubMed:17599910, PubMed:17952091, PubMed:31423530). May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics (PubMed:16965264, PubMed:17599910). Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity)
Protein Sequence
10
MAEVHRRQHA
20
RVKGEAPAKS
30
STLRDEEELG
40
MASAETLTVF
50
LKLLAAGFYG
60
VSSFLIVVVN
70
KSVLTNYRFP
80
SSLCVGLGQM
90
VATVAVLWVG
100
KALRVVKFPD
110
LDRNVPRKTF
120
PLPLLYFGNQ
130
ITGLFSTKKL
140
NLPMFTVLRR
150
FSILFTMFAE
160
GVLLKKTFSW
170
GIKMTVFAMI
180
IGAFVAASSD
190
LAFDLEGYAF
200
ILINDVLTAA
210
NGAYVKQKLD
220
SKELGKYGLL
230
YYNALFMILP
240
TLAIAYFTGD
250
AQKAVEFEGW
260
ADTLFLLQFT
270
LSCVMGFILM
280
YATVLCTQYN
290
SALTTTIVGC
300
IKNILITYIG
310
MVFGGDYIFT
320
WTNFIGLNIS
330
IAGSLVYSYI
340
TFTEEQLSKQ
350
SEANNKLDIK
GKGAV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Molecular Function |
GO:0015297 |
antiporter activity |
| Molecular Function |
GO:0005461 |
UDP-glucuronate transmembrane transporter activity |
| Molecular Function |
GO:0005463 |
UDP-N-acetylgalactosamine transmembrane transporter activity |
| Molecular Function |
GO:0005462 |
UDP-N-acetylglucosamine transmembrane transporter activity |
| Biological Process |
GO:0015780 |
nucleotide-sugar transmembrane transport |
| Biological Process |
GO:0090481 |
pyrimidine nucleotide-sugar transmembrane transport |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.