Search Results

Overview

Uniprot ID	Q9NTX5
Protein Name	Ethylmalonyl-CoA decarboxylase
Gene Name	ECHDC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
108	GLIVRGAKNTFSSGS
13	EMAKSLLKTASLSGR
217	KVLSGALKLDSKNAL
22	ASLSGRTKLLHQTGL

Function

Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer (By similarity). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity)

Protein Sequence

10 MALKQEMAKS 20 LLKTASLSGR 30 TKLLHQTGLS 40 LYSTSHGFYE 50 EEVKKTLQQF 60 PGGSIDLQKE 70 DNGIGILTLN 80 NPSRMNAFSG 90 VMMLQLLEKV 100 IELENWTEGK 110 GLIVRGAKNT 120 FSSGSDLNAV 130 KSLGTPEDGM 140 AVCMFMQNTL 150 TRFMRLPLIS 160 VALVQGWALG 170 GGAEFTTACD 180 FRLMTPESKI 190 RFVHKEMGII 200 PSWGGTTRLV 210 EIIGSRQALK 220 VLSGALKLDS 230 KNALNIGMVE 240 EVLQSSDETK 250 SLEEAQEWLK 260 QFIQGPPEVI 270 RALKKSVCSG 280 RELYLEEALQ 290 NERDLLGTVW 300 GGPANLEAIA KKGKFNK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0016831	carboxy-lyase activity
Molecular Function	GO:0004492	methyl/ethyl malonyl-CoA decarboxylase activity
Biological Process	GO:0006635	fatty acid beta-oxidation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.