Search Results

Overview

Uniprot IDQ9NU22
Protein NameMidasin
Gene NameMDN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1024 GNVKSLLKQPIPEPK
2657 LVSVGSKKLRESVLR
2905 LSLGFLEKKHDEASS
2906 SLGFLEKKHDEASSL

Function

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity)

Protein Sequence

10 MEHFLLEVAA 20 APLRLIAAKN 30 EKSRSELGRF 40 LAKQVWTPQD 50 RQCVLSTLAQ 60 LLLDKDCTVL 70 VGRQLRPLLL 80 DLLERNAEAI 90 KAGGQINHDL 100 HERLCVSMSK 110 LIGNHPDVLP 120 FALRYFKDTS 130 PVFQRLFLES 140 SDANPVRYGR 150 RRMKLRDLME 160 AAFKFLQQEQ 170 SVFRELWDWS 180 VCVPLLRSHD 190 TLVRWYTANC 200 LALVTCMNEE 210 HKLSFLKKIF 220 NSDELIHFRL 230 RLLEEAQLQD 240 LEKALVLANP 250 EVSLWRKQKE 260 LQYLQGHLVS 270 SDLSPRVTAV 280 CGVVLPGQLP 290 APGELGGNRS 300 SSREQELALR 310 SYVLVESVCK 320 SLQTLAMAVA 330 SQNAVLLEGP 340 IGCGKTSLVE 350 YLAAVTGRTK 360 PPQLLKVQLG 370 DQTDSKMLLG 380 MYRCTDVPGE 390 FVWQPGTLTQ 400 AATMGHWILL 410 EDIDYAPLDV 420 VSVLIPLLEN 430 GELLIPGRGD 440 CLKVAPGFQF 450 FATRRLLSCG 460 GNWYRPLNSH 470 ATLLDKYWTK 480 IHLDNLDKRE 490 LNEVLQSRYP 500 SLLAVVDHLL 510 DIYIQLTGEK 520 HHSWSDSSVG 530 CEQAPEEVSE 540 ARRENKRPTL 550 EGRELSLRDL 560 LNWCNRIAHS 570 FDSSSLSASL 580 NIFQEALDCF 590 TAMLSEHTSK 600 LKMAEVIGSK 610 LNISRKKAEF 620 FCQLYKPEIV 630 INELDLQVGR 640 VRLLRKQSEA 650 VHLQREKFTF 660 AATRPSSVLI 670 EQLAVCVSKG 680 EPVLLVGETG 690 TGKTSTIQYL 700 AHITGHRLRV 710 VNMNQQSDTA 720 DLLGGYKPVD 730 HKLIWLPLRE 740 AFEELFAQTF 750 SKKQNFTFLG 760 HIQTCYRQKR 770 WHDLLRLMQH 780 VHKSAVNKDG 790 KDSETGLLIK 800 EKWEAFGLRL 810 NHAQQQMKMT 820 ENTLLFAFVE 830 GTLAQAVKKG 840 EWILLDEINL 850 AAPEILECLS 860 GLLEGSSGSL 870 VLLDRGDTEP 880 LVRHPDFRLF 890 ACMNPATDVG 900 KRNLPPGIRN 910 RFTELYVEEL 920 ESKEDLQVLI 930 VDYLKGLSVN 940 KNTVQGIINF 950 YTALRKESGT 960 KLVDGTGHRP 970 HYSLRTLCRA 980 LRFAASNPCG 990 NIQRSLYEGF 1000 CLGFLTQLDR 1010 ASHPIVQKLI 1020 CQHIVPGNVK 1030 SLLKQPIPEP 1040 KGGRLIQVEG 1050 YWIAVGDKEP 1060 TIDETYILTS 1070 SVKLNLRDIV 1080 RVVSAGTYPV 1090 LIQGETSVGK 1100 TSLIQWLAAA 1110 TGNHCVRINN 1120 HEHTDIQEYI 1130 GCYTSDSSGK 1140 LVFKEGVLID 1150 AMRKGYWIIL 1160 DELNLAPTDV 1170 LEALNRLLDD 1180 NRELLVTETQ 1190 EVVKAHPRFM 1200 LFATQNPPGL 1210 YGGRKVLSRA 1220 FRNRFVELHF 1230 DELPSSELET 1240 ILHKRCSLPP 1250 SYCSKLVKVM 1260 LDLQSYRRSS 1270 SVFAGKQGFI 1280 TLRDLFRWAE 1290 RYRLAEPTEK 1300 EYDWLQHLAN 1310 DGYMLLAGRV 1320 RKQEEIDVIQ 1330 EVLEKHFKKK 1340 LCPQSLFSKE 1350 NVLKLLGKLS 1360 TQISTLECNF 1370 GHIVWTEGMR 1380 RLAMLVGRAL 1390 EFGEPVLLVG 1400 DTGCGKTTIC 1410 QVFAALANQK 1420 LYSVSCHLHM 1430 ETSDFLGGLR 1440 PVRQKPNDKE 1450 EIDTSRLFEW 1460 HDGPLVQAMK 1470 EDGFFLLDEI 1480 SLADDSVLER 1490 LNSVLEVEKS 1500 LVLAEKGSPE 1510 DKDSEIELLT 1520 AGKKFRILAT 1530 MNPGGDFGKK 1540 ELSPALRNRF 1550 TEIWCPQSTS 1560 REDLIQIISH 1570 NLRPGLCLGR 1580 IDPKGSDIPE 1590 VMLDFIDWLT 1600 HQEFGRKCVV 1610 SIRDILSWVN 1620 FMNKMGEEAA 1630 LKRPEIISTV 1640 TSFVHAACLV 1650 YIDGIGSGVT 1660 SSGFGTALLA 1670 RKECLKFLIK 1680 RLAKIVRLTE 1690 YQKNELKIYD 1700 RMKAKEFTGI 1710 DNLWGIHPFF 1720 IPRGPVLHRN 1730 NIADYALSAG 1740 TTAMNAQRLL 1750 RATKLKKPIL 1760 LEGSPGVGKT 1770 SLVGALAKAS 1780 GNTLVRINLS 1790 EQTDITDLFG 1800 ADLPVEGGKG 1810 GEFAWRDGPL 1820 LAALKAGHWV 1830 VLDELNLASQ 1840 SVLEGLNACF 1850 DHRGEIYVPE 1860 LGMSFQVQHE 1870 KTKIFGCQNP 1880 FRQGGGRKGL 1890 PRSFLNRFTQ 1900 VFVDPLTVID 1910 MEFIASTLFP 1920 AIEKNIVKKM 1930 VAFNNQIDHE 1940 VTVEKKWGQK 1950 GGPWEFNLRD 1960 LFRWCQLMLV 1970 DQSPGCYDPG 1980 QHVFLVYGER 1990 MRTEEDKKKV 2000 IAVFKDVFGS 2010 NSNPYMGTRL 2020 FRITPYDVQL 2030 GYSVLSRGSC 2040 VPHPSRHPLL 2050 LLHQSFQPLE 2060 SIMKCVQMSW 2070 MVILVGPASV 2080 GKTSLVQLLA 2090 HLTGHTLKIM 2100 AMNSAMDTTE 2110 LLGGFEQVDL 2120 IRPWRRLLEK 2130 VEGTVRALLR 2140 DSLLISADDA 2150 EVVLRAWSHF 2160 LLTYKPKCLG 2170 EGGKAITMEI 2180 VNKLEAVLLL 2190 MQRLNNKINS 2200 YCKAEFAKLV 2210 EEFRSFGVKL 2220 TQLASGHSHG 2230 TFEWVDSMLV 2240 QALKSGDWLL 2250 MDNVNFCNPS 2260 VLDRLNALLE 2270 PGGVLTISER 2280 GMIDGSTPTI 2290 TPNPNFRLFL 2300 SMDPVHGDIS 2310 RAMRNRGLEI 2320 YISGEGDAST 2330 PDNLDLKVLL 2340 HSLGLVGNSV 2350 CDILLALHTE 2360 TRSTVVGSPT 2370 SSVSTLIQTA 2380 ILIVQYLQRG 2390 LSLDRAFSEA 2400 CWEVYVCSQH 2410 SPANRKLVQA 2420 LLEKHVSSLR 2430 AHETWGDSIL 2440 GMGLWPDSVP 2450 SALFATEDSH 2460 LSTVRRDGQI 2470 LVYCLNRMSM 2480 KTSSWTRSQP 2490 FTLQDLEKIM 2500 QSPSPENLKF 2510 NAVEVNTYWI 2520 DEPDVLVMAV 2530 KLLIERATNQ 2540 DWMLRVKWLY 2550 HLAKNIPQGL 2560 ESIQIHLEAS 2570 AASLRNFYSH 2580 SLSGAVSNVF 2590 KILQPNTTDE 2600 FVIPLDPRWN 2610 MQALDMIRNL 2620 MDFDPQTDQP 2630 DQLFALLESA 2640 ANKTIIYLDR 2650 EKRVFTEANL 2660 VSVGSKKLRE 2670 SVLRMSFEFH 2680 QDPESYHTLP 2690 HEIVVNLAAF 2700 FELCDALVLL 2710 WVQSSQGMVS 2720 DASANEILGS 2730 LRWRDRFWTV 2740 ADTVKVDAPG 2750 LALLALHWHW 2760 VLKHLVHQIP 2770 RLLMNYEDKY 2780 YKEVQTVSEH 2790 IQNCLGSQTG 2800 GFAGIKKLQK 2810 FLGRPFPFKD 2820 KLVVECFSQL 2830 KVLNKVLAIR 2840 EQMSALGESG 2850 WQEDINRLQV 2860 VASQWTLKKS 2870 LLQAWGLILR 2880 ANILEDVSLD 2890 ELKNFVHAQC 2900 LELKAKGLSL 2910 GFLEKKHDEA 2920 SSLSHPDLTS 2930 VIHLTRSVQL 2940 WPAMEYLAML 2950 WRYKVTADFM 2960 AQACLRRCSK 2970 NQQPQINEEI 2980 SHLISFCLYH 2990 TPVTPQELRD 3000 LWSLLHHQKV 3010 SPEEITSLWS 3020 ELFNSMFMSF 3030 WSSTVTTNPE 3040 YWLMWNPLPG 3050 MQQREAPKSV 3060 LDSTLKGPGN 3070 LNRPIFSKCC 3080 FEVLTSSWRA 3090 SPWDVSGLPI 3100 LSSSHVTLGE 3110 WVERTQQLQD 3120 ISSMLWTNMA 3130 ISSVAEFRRT 3140 DSQLQGQVLF 3150 RHLAGLAELL 3160 PESRRQEYMQ 3170 NCEQLLLGSS 3180 QAFQHVGQTL 3190 GDMAGQEVLP 3200 KELLCQLLTS 3210 LHHFVGEGES 3220 KRSLPEPAQR 3230 GSLWVSLGLL 3240 QIQTWLPQAR 3250 FDPAVKREYK 3260 LNYVKEELHQ 3270 LQCEWKTRNL 3280 SSQLQTGRDL 3290 EDEVVVSYSH 3300 PHVRLLRQRM 3310 DRLDNLTCHL 3320 LKKQAFRPQL 3330 PAYESLVQEI 3340 HHYVTSIAKA 3350 PAVQDLLTRL 3360 LQALHIDGPR 3370 SAQVAQSLLK 3380 EEASWQQSHH 3390 QFRKRLSEEY 3400 TFYPDAVSPL 3410 QASILQLQHG 3420 MRLVASELHT 3430 SLHSSMVGAD 3440 RLGTLATALL 3450 AFPSVGPTFP 3460 TYYAHADTLC 3470 SVKSEEVLRG 3480 LGKLILKRSG 3490 GKELEGKGQK 3500 ACPTREQLLM 3510 NALLYLRSHV 3520 LCKGELDQRA 3530 LQLFRHVCQE 3540 IISEWDEQER 3550 IAQEKAEQES 3560 GLYRYRSRNS 3570 RTALSEEEEE 3580 EREFRKQFPL 3590 HEKDFADILV 3600 QPTLEENKGT 3610 SDGQEEEAGT 3620 NPALLSQNSM 3630 QAVMLIHQQL 3640 CLNFARSLWY 3650 QQTLPPHEAK 3660 HYLSLFLSCY 3670 QTGASLVTHF 3680 YPLMGVELND 3690 RLLGSQLLAC 3700 TLSHNTLFGE 3710 APSDLMVKPD 3720 GPYDFYQHPN 3730 VPEARQCQPV 3740 LQGFSEAVSH 3750 LLQDWPEHPA 3760 LEQLLVVMDR 3770 IRSFPLSSPI 3780 SKFLNGLEIL 3790 LAKAQDWEEN 3800 ASRALSLRKH 3810 LDLISQMIIR 3820 WRKLELNCWS 3830 MSLDNTMKRH 3840 TEKSTKHWFS 3850 IYQMLEKHMQ 3860 EQTEEQEDDK 3870 QMTLMLLVST 3880 LQAFIEGSSL 3890 GEFHVRLQML 3900 LVFHCHVLLM 3910 PQVEGKDSLC 3920 SVLWNLYHYY 3930 KQFFDRVQAK 3940 IVELRSPLEK 3950 ELKEFVKISK 3960 WNDVSFWSIK 3970 QSVEKTHRTL 3980 FKFMKKFEAV 3990 LSEPCRSSLV 4000 ESDKEEQPDF 4010 LPRPTDGAAS 4020 ELSSIQNLNR 4030 ALRETLLAQP 4040 AAGQATIPEW 4050 CQGAAPSGLE 4060 GELLRRLPKL 4070 RKRMRKMCLT 4080 FMKESPLPRL 4090 VEGLDQFTGE 4100 VISSVSELQS 4110 LKVEPSAEKE 4120 KQRSEAKHIL 4130 MQKQRALSDL 4140 FKHLAKIGLS 4150 YRKGLAWARS 4160 KNPQEMLHLH 4170 PLDLQSALSI 4180 VSSTQEADSR 4190 LLTEISSSWD 4200 GCQKYFYRSL 4210 ARHARLNAAL 4220 ATPAKEMGMG 4230 NVERCRGFSA 4240 HLMKMLVRQR 4250 RSLTTLSEQW 4260 IILRNLLSCV 4270 QEIHSRLMGP 4280 QAYPVAFPPQ 4290 DGVQQWTERL 4300 QHLAMQCQIL 4310 LEQLSWLLQC 4320 CPSVGPAPGH 4330 GNVQVLGQPP 4340 GPCLEGPELS 4350 KGQLCGVVLD 4360 LIPSNLSYPS 4370 PIPGSQLPSG 4380 CRMRKQDHLW 4390 QQSTTRLTEM 4400 LKTIKTVKAD 4410 VDKIRQQSCE 4420 TLFHSWKDFE 4430 VCSSALSCLS 4440 QVSVHLQGLE 4450 SLFILPGMEV 4460 EQRDSQMALV 4470 ESLEYVRGEI 4480 SKAMADFTTW 4490 KTHLLTSDSQ 4500 GGNQMLDEGF 4510 VEDFSEQMEI 4520 AIRAILCAIQ 4530 NLEERKNEKA 4540 EENTDQASPQ 4550 EDYAGFERLQ 4560 SGHLTKLLED 4570 DFWADVSTLH 4580 VQKIISAISE 4590 LLERLKSYGE 4600 DGTAAKHLFF 4610 SQSCSLLVRL 4620 VPVLSSYSDL 4630 VLFFLTMSLA 4640 THRSTAKLLS 4650 VLAQVFTELA 4660 QKGFCLPKEF 4670 MEDSAGEGAT 4680 EFHDYEGGGI 4690 GEGEGMKDVS 4700 DQIGNEEQVE 4710 DTFQKGQEKD 4720 KEDPDSKSDI 4730 KGEDNAIEMS 4740 EDFDGKMHDG 4750 ELEEQEEDDE 4760 KSDSEGGDLD 4770 KHMGDLNGEE 4780 ADKLDERLWG 4790 DDDEEEDEEE 4800 EDNKTEETGP 4810 GMDEEDSELV 4820 AKDDNLDSGN 4830 SNKDKSQQDK 4840 KEEKEEAEAD 4850 DGGQGEDKIN 4860 EQIDERDYDE 4870 NEVDPYHGNQ 4880 EKVPEPEALD 4890 LPDDLNLDSE 4900 DKNGGEDTDN 4910 EEGEEENPLE 4920 IKEKPEEAGH 4930 EAEERGETET 4940 DQNESQSPQE 4950 PEEGPSEDDK 4960 AEGEEEMDTG 4970 ADDQDGDAAQ 4980 HPEEHSEEQQ 4990 QSVEEKDKEA 5000 DEEGGENGPA 5010 DQGFQPQEEE 5020 EREDSDTEEQ 5030 VPEALERKEH 5040 ASCGQTGVEN 5050 MQNTQAMELA 5060 GAAPEKEQGK 5070 EEHGSGAADA 5080 NQAEGHESNF 5090 IAQLASQKHT 5100 RKNTQSFKRK 5110 PGQADNERSM 5120 GDHNERVHKR 5130 LRTVDTDSHA 5140 EQGPAQQPQA 5150 QVEDADAFEH 5160 IKQGSDAYDA 5170 QTYDVASKEQ 5180 QQSAKDSGKD 5190 QEEEEIEDTL 5200 MDTEEQEEFK 5210 AADVEQLKPE 5220 EIKSGTTAPL 5230 GFDEMEVEIQ 5240 TVKTEEDQDP 5250 RTDKAHKETE 5260 NEKPERSRES 5270 TIHTAHQFLM 5280 DTIFQPFLKD 5290 VNELRQELER 5300 QLEMWQPRES 5310 GNPEEEKVAA 5320 EMWQSYLILT 5330 APLSQRLCEE 5340 LRLILEPTQA 5350 AKLKGDYRTG 5360 KRLNIRKVIP 5370 YIASQFRKDK 5380 IWLRRTKPSK 5390 RQYQICLAID 5400 DSSSMVDNHT 5410 KQLAFESLAV 5420 IGNALTLLEV 5430 GQIAVCSFGE 5440 SVKLLHPFHE 5450 QFSDYSGSQI 5460 LRLCKFQQKK 5470 TKIAQFLESV 5480 ANMFAAAQQL 5490 SQNISSETAQ 5500 LLLVVSDGRG 5510 LFLEGKERVL 5520 AAVQAARNAN 5530 IFVIFVVLDN 5540 PSSRDSILDI 5550 KVPIFKGPGE 5560 MPEIRSYMEE 5570 FPFPYYIILR 5580 DVNALPETLS 5590 DALRQWFELV TASDHP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000027 ribosomal large subunit assembly

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.