Search Results
Overview
| Uniprot ID | Q9NUB1 |
|---|---|
| Protein Name | Acetyl-coenzyme A synthetase 2-like, mitochondrial |
| Gene Name | ACSS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 622 | MVATKIAKYAVPDEI |
| 650 | VMRRLLRKIITSEAQ |
Function
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity)
Protein Sequence
10
MAARTLGRGV
20
GRLLGSLRGL
30
SGQPARPPCG
40
VSAPRRAASG
50
PSGSAPAVAA
60
AAAQPGSYPA
70
LSAQAAREPA
80
AFWGPLARDT
90
LVWDTPYHTV
100
WDCDFSTGKI
110
GWFLGGQLNV
120
SVNCLDQHVR
130
KSPESVALIW
140
ERDEPGTEVR
150
ITYRELLETT
160
CRLANTLKRH
170
GVHRGDRVAI
180
YMPVSPLAVA
190
AMLACARIGA
200
VHTVIFAGFS
210
AESLAGRIND
220
AKCKVVITFN
230
QGLRGGRVVE
240
LKKIVDEAVK
250
HCPTVQHVLV
260
AHRTDNKVHM
270
GDLDVPLEQE
280
MAKEDPVCAP
290
ESMGSEDMLF
300
MLYTSGSTGM
310
PKGIVHTQAG
320
YLLYAALTHK
330
LVFDHQPGDI
340
FGCVADIGWI
350
TGHSYVVYGP
360
LCNGATSVLF
370
ESTPVYPNAG
380
RYWETVERLK
390
INQFYGAPTA
400
VRLLLKYGDA
410
WVKKYDRSSL
420
RTLGSVGEPI
430
NCEAWEWLHR
440
VVGDSRCTLV
450
DTWWQTETGG
460
ICIAPRPSEE
470
GAEILPAMAM
480
RPFFGIVPVL
490
MDEKGSVVEG
500
SNVSGALCIS
510
QAWPGMARTI
520
YGDHQRFVDA
530
YFKAYPGYYF
540
TGDGAYRTEG
550
GYYQITGRMD
560
DVINISGHRL
570
GTAEIEDAIA
580
DHPAVPESAV
590
IGYPHDIKGE
600
AAFAFIVVKD
610
SAGDSDVVVQ
620
ELKSMVATKI
630
AKYAVPDEIL
640
VVKRLPKTRS
650
GKVMRRLLRK
660
IITSEAQELG
670
DTTTLEDPSI
680
IAEILSVYQK
CKDKQAAAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003987 | acetate-CoA ligase activity |
| Molecular Function | GO:0016208 | AMP binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0050218 | propionate-CoA ligase activity |
| Biological Process | GO:0019413 | acetate biosynthetic process |
| Biological Process | GO:0006085 | acetyl-CoA biosynthetic process |
| Biological Process | GO:0019427 | acetyl-CoA biosynthetic process from acetate |
| Biological Process | GO:0006068 | ethanol catabolic process |
| Biological Process | GO:0019542 | propionate biosynthetic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.