Search Results
Overview
| Uniprot ID | Q9NUI1 |
|---|---|
| Protein Name | Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] |
| Gene Name | DECR2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 230 | PQASLSTKVTASPLQ |
Function
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid
Protein Sequence
10
MAQPPPDVEG
20
DDCLPAYRHL
30
FCPDLLRDKV
40
AFITGGGSGI
50
GFRIAEIFMR
60
HGCHTVIASR
70
SLPRVLTAAR
80
KLAGATGRRC
90
LPLSMDVRAP
100
PAVMAAVDQA
110
LKEFGRIDIL
120
INCAAGNFLC
130
PAGALSFNAF
140
KTVMDIDTSG
150
TFNVSRVLYE
160
KFFRDHGGVI
170
VNITATLGNR
180
GQALQVHAGS
190
AKAAVDAMTR
200
HLAVEWGPQN
210
IRVNSLAPGP
220
ISGTEGLRRL
230
GGPQASLSTK
240
VTASPLQRLG
250
NKTEIAHSVL
260
YLASPLASYV
270
TGAVLVADGG
280
AWLTFPNGVK
290
GLPDFASFSA
KL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity |
| Molecular Function | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity |
| Biological Process | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0006636 | unsaturated fatty acid biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.