Search Results

Overview

Uniprot ID	Q9NUJ1
Protein Name	Palmitoyl-protein thioesterase ABHD10, mitochondrial
Gene Name	ABHD10
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
101	LAIEEFCKSLGHACI

Function

Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (PubMed:22294686)

Protein Sequence

10 MAVARLAAVA 20 AWVPCRSWGW 30 AAVPFGPHRG 40 LSVLLARIPQ 50 RAPRWLPACR 60 QKTSLSFLNR 70 PDLPNLAYKK 80 LKGKSPGIIF 90 IPGYLSYMNG 100 TKALAIEEFC 110 KSLGHACIRF 120 DYSGVGSSDG 130 NSEESTLGKW 140 RKDVLSIIDD 150 LADGPQILVG 160 SSLGGWLMLH 170 AAIARPEKVV 180 ALIGVATAAD 190 TLVTKFNQLP 200 VELKKEVEMK 210 GVWSMPSKYS 220 EEGVYNVQYS 230 FIKEAEHHCL 240 LHSPIPVNCP 250 IRLLHGMKDD 260 IVPWHTSMQV 270 ADRVLSTDVD 280 VILRKHSDHR 290 MREKADIQLL 300 VYTIDDLIDK LSTIVN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
Molecular Function	GO:0102390	mycophenolic acid acyl-glucuronide esterase activity
Molecular Function	GO:0008474	palmitoyl-(protein) hydrolase activity
Biological Process	GO:0019585	glucuronate metabolic process
Biological Process	GO:0002084	protein depalmitoylation
Biological Process	GO:0006805	xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.