Search Results

Overview

Uniprot IDQ9NUQ8
Protein NameATP-binding cassette sub-family F member 3
Gene NameABCF3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 ENYDCGTKLPGLLKR
457 RASQVQSKLKMLEKL

Function

Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B

Protein Sequence

10 MATCAEILRS 20 EFPEIDGQVF 30 DYVTGVLHSG 40 SADFESVDDL 50 VEAVGELLQE 60 VSGDSKDDAG 70 IRAVCQRMYN 80 TLRLAEPQSQ 90 GNSQVLLDAP 100 IQLSKITENY 110 DCGTKLPGLL 120 KREQSSTVNA 130 KKLEKAEARL 140 KAKQEKRSEK 150 DTLKTSNPLV 160 LEEASASQAG 170 SRKESRLESS 180 GKNKSYDVRI 190 ENFDVSFGDR 200 VLLAGADVNL 210 AWGRRYGLVG 220 RNGLGKTTLL 230 KMLATRSLRV 240 PAHISLLHVE 250 QEVAGDDTPA 260 LQSVLESDSV 270 REDLLRRERE 280 LTAQIAAGRA 290 EGSEAAELAE 300 IYAKLEEIEA 310 DKAPARASVI 320 LAGLGFTPKM 330 QQQPTREFSG 340 GWRMRLALAR 350 ALFARPDLLL 360 LDEPTNMLDV 370 RAILWLENYL 380 QTWPSTILVV 390 SHDRNFLNAI 400 ATDIIHLHSQ 410 RLDGYRGDFE 420 TFIKSKQERL 430 LNQQREYEAQ 440 QQYRQHIQVF 450 IDRFRYNANR 460 ASQVQSKLKM 470 LEKLPELKPV 480 DKESEVVMKF 490 PDGFEKFSPP 500 ILQLDEVDFY 510 YDPKHVIFSR 520 LSVSADLESR 530 ICVVGENGAG 540 KSTMLKLLLG 550 DLAPVRGIRH 560 AHRNLKIGYF 570 SQHHVEQLDL 580 NVSAVELLAR 590 KFPGRPEEEY 600 RHQLGRYGIS 610 GELAMRPLAS 620 LSGGQKSRVA 630 FAQMTMPCPN 640 FYILDEPTNH 650 LDMETIEALG 660 RALNNFRGGV 670 ILVSHDERFI 680 RLVCRELWVC 690 EGGGVTRVEG 700 GFDQYRALLQ EQFRREGFL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0045296 cadherin binding
Biological Process GO:0051607 defense response to virus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.