Search Results

Overview

Uniprot IDQ9NUQ9
Protein NameCYFIP-related Rac1 interactor B
Gene NameCYRIB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
317 LNDETTSKQIKSMLQ

Function

Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:30250061, PubMed:31285585). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164)

Protein Sequence

10 MGNLLKVLTC 20 TDLEQGPNFF 30 LDFENAQPTE 40 SEKEIYNQVN 50 VVLKDAEGIL 60 EDLQSYRGAG 70 HEIREAIQHP 80 ADEKLQEKAW 90 GAVVPLVGKL 100 KKFYEFSQRL 110 EAALRGLLGA 120 LTSTPYSPTQ 130 HLEREQALAK 140 QFAEILHFTL 150 RFDELKMTNP 160 AIQNDFSYYR 170 RTLSRMRINN 180 VPAEGENEVN 190 NELANRMSLF 200 YAEATPMLKT 210 LSDATTKFVS 220 ENKNLPIENT 230 TDCLSTMASV 240 CRVMLETPEY 250 RSRFTNEETV 260 SFCLRVMVGV 270 IILYDHVHPV 280 GAFAKTSKID 290 MKGCIKVLKD 300 QPPNSVEGLL 310 NALRYTTKHL 320 NDETTSKQIK SMLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005929 cilium
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0016020 membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0031093 platelet alpha granule lumen
Molecular Function GO:0023030 MHC class Ib protein binding, via antigen binding groove
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0071219 cellular response to molecule of bacterial origin
Biological Process GO:0030837 negative regulation of actin filament polymerization
Biological Process GO:0051058 negative regulation of small GTPase mediated signal transduction
Biological Process GO:2000568 positive regulation of memory T cell activation
Biological Process GO:0050870 positive regulation of T cell activation
Biological Process GO:0001916 positive regulation of T cell mediated cytotoxicity
Biological Process GO:0032729 positive regulation of type II interferon production
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0050920 regulation of chemotaxis
Biological Process GO:2000114 regulation of establishment of cell polarity
Biological Process GO:0090140 regulation of mitochondrial fission

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.