Overview
| Uniprot ID | Q9NUT2 |
|---|
| Protein Name | Mitochondrial potassium channel ATP-binding subunit |
|---|
| Gene Name | ABCB8 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 263 |
TTDVQEFKSSFKLVI |
Function
ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane (PubMed:31435016). An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (PubMed:31435016). Plays a role in mitochondrial iron transport (PubMed:30623799). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity)
Protein Sequence
10
MLVHLFRVGI
20
RGGPFPGRLL
30
PPLRFQTFSA
40
VRNTWRNGKT
50
GQLHKAEGEY
60
SDGYRSSSLL
70
RAVAHLRSQL
80
WAHLPRAPLA
90
PRWSPSAWCW
100
VGGALLGPMV
110
LSKHPHLCLV
120
ALCEAEEAPP
130
ASSTPHVVGS
140
RFNWKLFWQF
150
LHPHLLVLGV
160
AVVLALGAAL
170
VNVQIPLLLG
180
QLVEVVAKYT
190
RDHVGSFMTE
200
SQNLSTHLLI
210
LYGVQGLLTF
220
GYLVLLSHVG
230
ERMAVDMRRA
240
LFSSLLRQDI
250
TFFDANKTGQ
260
LVSRLTTDVQ
270
EFKSSFKLVI
280
SQGLRSCTQV
290
AGCLVSLSML
300
STRLTLLLMV
310
ATPALMGVGT
320
LMGSGLRKLS
330
RQCQEQIARA
340
MGVADEALGN
350
VRTVRAFAME
360
QREEERYGAE
370
LEACRCRAEE
380
LGRGIALFQG
390
LSNIAFNCMV
400
LGTLFIGGSL
410
VAGQQLTGGD
420
LMSFLVASQT
430
VQRSMANLSV
440
LFGQVVRGLS
450
AGARVFEYMA
460
LNPCIPLSGG
470
CCVPKEQLRG
480
SVTFQNVCFS
490
YPCRPGFEVL
500
KDFTLTLPPG
510
KIVALVGQSG
520
GGKTTVASLL
530
ERFYDPTAGV
540
VMLDGRDLRT
550
LDPSWLRGQV
560
VGFISQEPVL
570
FGTTIMENIR
580
FGKLEASDEE
590
VYTAAREANA
600
HEFITSFPEG
610
YNTVVGERGT
620
TLSGGQKQRL
630
AIARALIKQP
640
TVLILDEATS
650
ALDAESERVV
660
QEALDRASAG
670
RTVLVIAHRL
680
STVRGAHCIV
690
VMADGRVWEA
700
GTHEELLKKG
710
GLYAELIRRQ
720
ALDAPRTAAP
730
PPKKPEGPRS
HQHKS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0043190 |
ATP-binding cassette (ABC) transporter complex |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0062157 |
mitochondrial ATP-gated potassium channel complex |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0140359 |
ABC-type transporter activity |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0042626 |
ATPase-coupled transmembrane transporter activity |
| Biological Process |
GO:0006884 |
cell volume homeostasis |
| Biological Process |
GO:0140141 |
mitochondrial potassium ion transmembrane transport |
| Biological Process |
GO:0071805 |
potassium ion transmembrane transport |
| Biological Process |
GO:0055085 |
transmembrane transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.