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Overview

Uniprot IDQ9NUV9
Protein NameGTPase IMAP family member 4
Gene NameGIMAP4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
63 FHSGTAAKSITKKCE

Function

During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP

Protein Sequence

10 MAAQYGSMSF 20 NPSTPGASYG 30 PGRQEPRNSQ 40 LRIVLVGKTG 50 AGKSATGNSI 60 LGRKVFHSGT 70 AAKSITKKCE 80 KRSSSWKETE 90 LVVVDTPGIF 100 DTEVPNAETS 110 KEIIRCILLT 120 SPGPHALLLV 130 VPLGRYTEEE 140 HKATEKILKM 150 FGERARSFMI 160 LIFTRKDDLG 170 DTNLHDYLRE 180 APEDIQDLMD 190 IFGDRYCALN 200 NKATGAEQEA 210 QRAQLLGLIQ 220 RVVRENKEGC 230 YTNRMYQRAE 240 EEIQKQTQAM 250 QELHRVELER 260 EKARIREEYE 270 EKIRKLEDKV 280 EQEKRKKQME 290 KKLAEQEAHY 300 AVRQQRARTE 310 VESKDGILEL 320 IMTALQIASF ILLRLFAED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.