Search Results
Overview
| Uniprot ID | Q9NV06 |
|---|---|
| Protein Name | DDB1- and CUL4-associated factor 13 |
| Gene Name | DCAF13 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 49 | IRALNATKLERVFAK |
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition (PubMed:30283081)
Protein Sequence
10
MKVKMLSRNP
20
DNYVRETKLD
30
LQRVPRNYDP
40
ALHPFEVPRE
50
YIRALNATKL
60
ERVFAKPFLA
70
SLDGHRDGVN
80
CLAKHPEKLA
90
TVLSGACDGE
100
VRIWNLTQRN
110
CIRTIQAHEG
120
FVRGICTRFC
130
GTSFFTVGDD
140
KTVKQWKMDG
150
PGYGDEEEPL
160
HTILGKTVYT
170
GIDHHWKEAV
180
FATCGQQVDI
190
WDEQRTNPIC
200
SMTWGFDSIS
210
SVKFNPIETF
220
LLGSCASDRN
230
IVLYDMRQAT
240
PLKKVILDMR
250
TNTICWNPME
260
AFIFTAANED
270
YNLYTFDMRA
280
LDTPVMVHMD
290
HVSAVLDVDY
300
SPTGKEFVSA
310
SFDKSIRIFP
320
VDKSRSREVY
330
HTKRMQHVIC
340
VKWTSDSKYI
350
MCGSDEMNIR
360
LWKANASEKL
370
GVLTSREKAA
380
KDYNQKLKEK
390
FQHYPHIKRI
400
ARHRHLPKSI
410
YSQIQEQRIM
420
KEARRRKEVN
430
RIKHSKPGSV
440
PLVSEKKKHV
VAVVK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0032040 | small-subunit processome |
| Molecular Function | GO:0030331 | nuclear estrogen receptor binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity |
| Biological Process | GO:0046697 | decidualization |
| Biological Process | GO:0044725 | epigenetic programming in the zygotic pronuclei |
| Biological Process | GO:0040029 | epigenetic regulation of gene expression |
| Biological Process | GO:0030490 | maturation of SSU-rRNA |
| Biological Process | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process | GO:0001555 | oocyte growth |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0006364 | rRNA processing |
| Biological Process | GO:0007056 | spindle assembly involved in female meiosis |
Reference
PMID: N/A