Search Results
Overview
| Uniprot ID | Q9NV31 |
|---|---|
| Protein Name | U3 small nucleolar ribonucleoprotein protein IMP3 |
| Gene Name | IMP3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 6 | **MVRKLKFHEQKLL |
Function
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)
Protein Sequence
10
MVRKLKFHEQ
20
KLLKQVDFLN
30
WEVTDHNLHE
40
LRVLRRYRLQ
50
RREDYTRYNQ
60
LSRAVRELAR
70
RLRDLPERDQ
80
FRVRASAALL
90
DKLYALGLVP
100
TRGSLELCDF
110
VTASSFCRRR
120
LPTVLLKLRM
130
AQHLQAAVAF
140
VEQGHVRVGP
150
DVVTDPAFLV
160
TRSMEDFVTW
170
VDSSKIKRHV
180
LEYNEERDDF
DLEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034457 | Mpp10 complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030684 | preribosome |
| Cellular Component | GO:0032040 | small-subunit processome |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0019843 | rRNA binding |
| Molecular Function | GO:0030515 | snoRNA binding |
| Biological Process | GO:0030490 | maturation of SSU-rRNA |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
| Biological Process | GO:0006364 | rRNA processing |
Reference
PMID: N/A