Search Results

Overview

Uniprot IDQ9NVA2
Protein NameSeptin-11
Gene NameSEPTIN11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
195 IAKNELHKFKSKIMS
366 AEKELHEKFDLLKRT
397 EEVNNFQKKKAAAQL
399 VNNFQKKKAAAQLLQ
418 QSGAQQTKKDKDKKN
419 SGAQQTKKDKDKKNA

Function

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy

Protein Sequence

10 MAVAVGRPSN 20 EELRNLSLSG 30 HVGFDSLPDQ 40 LVNKSTSQGF 50 CFNILCVGET 60 GIGKSTLMDT 70 LFNTKFESDP 80 ATHNEPGVRL 90 KARSYELQES 100 NVRLKLTIVD 110 TVGFGDQINK 120 DDSYKPIVEY 130 IDAQFEAYLQ 140 EELKIKRSLF 150 NYHDTRIHAC 160 LYFIAPTGHS 170 LKSLDLVTMK 180 KLDSKVNIIP 190 IIAKADTIAK 200 NELHKFKSKI 210 MSELVSNGVQ 220 IYQFPTDEET 230 VAEINATMSV 240 HLPFAVVGST 250 EEVKIGNKMA 260 KARQYPWGVV 270 QVENENHCDF 280 VKLREMLIRV 290 NMEDLREQTH 300 TRHYELYRRC 310 KLEEMGFKDT 320 DPDSKPFSLQ 330 ETYEAKRNEF 340 LGELQKKEEE 350 MRQMFVMRVK 360 EKEAELKEAE 370 KELHEKFDLL 380 KRTHQEEKKK 390 VEDKKKELEE 400 EVNNFQKKKA 410 AAQLLQSQAQ 420 QSGAQQTKKD KDKKNASFT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0032153 cell division site
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0031105 septin complex
Cellular Component GO:0005940 septin ring
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0060090 molecular adaptor activity
Biological Process GO:0061640 cytoskeleton-dependent cytokinesis
Biological Process GO:0008104 intracellular protein localization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.