Search Results
Overview
| Uniprot ID | Q9NVC6 |
|---|---|
| Protein Name | Mediator of RNA polymerase II transcription subunit 17 |
| Gene Name | MED17 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 356 | SNDKKSQKFATEKQC |
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
Protein Sequence
10
MSGVRAVRIS
20
IESACEKQVH
30
EVGLDGTETY
40
LPPLSMSQNL
50
ARLAQRIDFS
60
QGSGSEEEEA
70
AGTEGDAQEW
80
PGAGSSADQD
90
DEEGVVKFQP
100
SLWPWDSVRN
110
NLRSALTEMC
120
VLYDVLSIVR
130
DKKFMTLDPV
140
SQDALPPKQN
150
PQTLQLISKK
160
KSLAGAAQIL
170
LKGAERLTKS
180
VTENQENKLQ
190
RDFNSELLRL
200
RQHWKLRKVG
210
DKILGDLSYR
220
SAGSLFPHHG
230
TFEVIKNTDL
240
DLDKKIPEDY
250
CPLDVQIPSD
260
LEGSAYIKVS
270
IQKQAPDIGD
280
LGTVNLFKRP
290
LPKSKPGSPH
300
WQTKLEAAQN
310
VLLCKEIFAQ
320
LSREAVQIKS
330
QVPHIVVKNQ
340
IISQPFPSLQ
350
LSISLCHSSN
360
DKKSQKFATE
370
KQCPEDHLYV
380
LEHNLHLLIR
390
EFHKQTLSSI
400
MMPHPASAPF
410
GHKRMRLSGP
420
QAFDKNEINS
430
LQSSEGLLEK
440
IIKQAKHIFL
450
RSRAAATIDS
460
LASRIEDPQI
470
QAHWSNINDV
480
YESSVKVLIT
490
SQGYEQICKS
500
IQLQLNIGVE
510
QIRVVHRDGR
520
VITLSYQEQE
530
LQDFLLSQMS
540
QHQVHAVQQL
550
AKVMGWQVLS
560
FSNHVGLGPI
570
ESIGNASAIT
580
VASPSGDYAI
590
SVRNGPESGS
600
KIMVQFPRNQ
610
CKDLPKSDVL
620
QDNKWSHLRG
630
PFKEVQWNKM
640
EGRNFVYKME
650
LLMSALSPCL
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0070847 | core mediator complex |
| Cellular Component | GO:0016592 | mediator complex |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Cellular Component | GO:0000151 | ubiquitin ligase complex |
| Molecular Function | GO:0046966 | nuclear thyroid hormone receptor binding |
| Molecular Function | GO:0042809 | nuclear vitamin D receptor binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II |
| Biological Process | GO:0060261 | positive regulation of transcription initiation by RNA polymerase II |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051123 | RNA polymerase II preinitiation complex assembly |
| Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.