Search Results

Overview

Uniprot IDQ9NVD7
Protein NameAlpha-parvin
Gene NamePARVA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
32 KDDSFLGKLGGTLAR

Function

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047)

Protein Sequence

10 MATSPQKSPS 20 VPKSPTPKSP 30 PSRKKDDSFL 40 GKLGGTLARR 50 KKAKEVSELQ 60 EEGMNAINLP 70 LSPIPFELDP 80 EDTMLEENEV 90 RTMVDPNSRS 100 DPKLQELMKV 110 LIDWINDVLV 120 GERIIVKDLA 130 EDLYDGQVLQ 140 KLFEKLESEK 150 LNVAEVTQSE 160 IAQKQKLQTV 170 LEKINETLKL 180 PPRSIKWNVD 190 SVHAKSLVAI 200 LHLLVALSQY 210 FRAPIRLPDH 220 VSIQVVVVQK 230 REGILQSRQI 240 QEEITGNTEA 250 LSGRHERDAF 260 DTLFDHAPDK 270 LNVVKKTLIT 280 FVNKHLNKLN 290 LEVTELETQF 300 ADGVYLVLLM 310 GLLEGYFVPL 320 HSFFLTPDSF 330 EQKVLNVSFA 340 FELMQDGGLE 350 KPKPRPEDIV 360 NCDLKSTLRV 370 LYNLFTKYRN VE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0004860 protein kinase inhibitor activity
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051017 actin filament bundle assembly
Biological Process GO:0051639 actin filament network formation
Biological Process GO:0070252 actin-mediated cell contraction
Biological Process GO:0060271 cilium assembly
Biological Process GO:0007163 establishment or maintenance of cell polarity
Biological Process GO:0071963 establishment or maintenance of cell polarity regulating cell shape
Biological Process GO:0034113 heterotypic cell-cell adhesion
Biological Process GO:0003148 outflow tract septum morphogenesis
Biological Process GO:0050821 protein stabilization
Biological Process GO:0071670 smooth muscle cell chemotaxis
Biological Process GO:0002040 sprouting angiogenesis
Biological Process GO:0034446 substrate adhesion-dependent cell spreading

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.