Overview
| Uniprot ID | Q9NVE7 |
|---|
| Protein Name | 4'-phosphopantetheine phosphatase |
|---|
| Gene Name | PANK4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 171 |
HEAFVYQKDSDPEFR |
Function
Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable)
Protein Sequence
10
MAECGASGSG
20
SSGDSLDKSI
30
TLPPDEIFRN
40
LENAKRFAID
50
IGGSLTKLAY
60
YSTVQHKVAK
70
VRSFDHSGKD
80
TEREHEPPYE
90
ISVQEEITAR
100
LHFIKFENTY
110
IEACLDFIKD
120
HLVNTETKVI
130
QATGGGAYKF
140
KDLIEEKLRL
150
KVDKEDVMTC
160
LIKGCNFVLK
170
NIPHEAFVYQ
180
KDSDPEFRFQ
190
TNHPHIFPYL
200
LVNIGSGVSI
210
VKVETEDRFE
220
WVGGSSIGGG
230
TFWGLGALLT
240
KTKKFDELLH
250
LASRGQHSNV
260
DMLVRDVYGG
270
AHQTLGLSGN
280
LIASSFGKSA
290
TADQEFSKED
300
MAKSLLHMIS
310
NDIGQLACLH
320
ARLHSLDRVY
330
FGGFFIRGHP
340
VTMRTITYSI
350
NFFSKGEVQA
360
LFLRHEGYLG
370
AIGAFLKGAE
380
QDNPNQYSWG
390
ENYAGSSGLM
400
SASPELGPAQ
410
RARSGTFDLL
420
EMDRLERPLV
430
DLPLLLDPPS
440
YVPDTVDLTD
450
DALARKYWLT
460
CFEEALDGVV
470
KRAVASQPDS
480
VDAAERAEKF
490
RQKYWNKLQT
500
LRQQPFAYGT
510
LTVRSLLDTR
520
EHCLNEFNFP
530
DPYSKVKQRE
540
NGVALRCFPG
550
VVRSLDALGW
560
EERQLALVKG
570
LLAGNVFDWG
580
AKAVSAVLES
590
DPYFGFEEAK
600
RKLQERPWLV
610
DSYSEWLQRL
620
KGPPHKCALI
630
FADNSGIDII
640
LGVFPFVREL
650
LLRGTEVILA
660
CNSGPALNDV
670
THSESLIVAE
680
RIAGMDPVVH
690
SALQEERLLL
700
VQTGSSSPCL
710
DLSRLDKGLA
720
ALVRERGADL
730
VVIEGMGRAV
740
HTNYHAALRC
750
ESLKLAVIKN
760
AWLAERLGGR
770
LFSVIFKYEV
PAE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0016791 |
phosphatase activity |
| Biological Process |
GO:0015937 |
coenzyme A biosynthetic process |
| Biological Process |
GO:0015939 |
pantothenate metabolic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.