Search Results
Overview
| Uniprot ID | Q9NVH6 |
|---|---|
| Protein Name | Trimethyllysine dioxygenase, mitochondrial |
| Gene Name | TMLHE |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | ASVDLCIKPKTIRLD |
| 236 | RGDTAYTKLALDRHT |
| 373 | PENEFWVKLKPGRVL |
Function
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) in the carnitine biosynthesis pathway
Protein Sequence
10
MWYHRLSHLH
20
SRLQDLLKGG
30
VIYPALPQPN
40
FKSLLPLAVH
50
WHHTASKSLT
60
CAWQQHEDHF
70
ELKYANTVMR
80
FDYVWLRDHC
90
RSASCYNSKT
100
HQRSLDTASV
110
DLCIKPKTIR
120
LDETTLFFTW
130
PDGHVTKYDL
140
NWLVKNSYEG
150
QKQKVIQPRI
160
LWNAEIYQQA
170
QVPSVDCQSF
180
LETNEGLKKF
190
LQNFLLYGIA
200
FVENVPPTQE
210
HTEKLAERIS
220
LIRETIYGRM
230
WYFTSDFSRG
240
DTAYTKLALD
250
RHTDTTYFQE
260
PCGIQVFHCL
270
KHEGTGGRTL
280
LVDGFYAAEQ
290
VLQKAPEEFE
300
LLSKVPLKHE
310
YIEDVGECHN
320
HMIGIGPVLN
330
IYPWNKELYL
340
IRYNNYDRAV
350
INTVPYDVVH
360
RWYTAHRTLT
370
IELRRPENEF
380
WVKLKPGRVL
390
FIDNWRVLHG
400
RECFTGYRQL
410
CGCYLTRDDV
420
LNTARLLGLQ
A
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0050353 | trimethyllysine dioxygenase activity |
| Biological Process | GO:0045329 | carnitine biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.