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Overview

Uniprot IDQ9NVI1
Protein NameFanconi anemia group I protein
Gene NameFANCI
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
12 ILSLAAEKTADKLQE
1229 SLNYTGEKKEKPAAV
148 KENLAYGKGVLSGEE

Function

Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789)

Protein Sequence

10 MDQKILSLAA 20 EKTADKLQEF 30 LQTLREGDLT 40 NLLQNQAVKG 50 KVAGALLRAI 60 FKGSPCSEEA 70 GTLRRRKIYT 80 CCIQLVESGD 90 LQKEIASEII 100 GLLMLEAHHF 110 PGPLLVELAN 120 EFISAVREGS 130 LVNGKSLELL 140 PIILTALATK 150 KENLAYGKGV 160 LSGEECKKQL 170 INTLCSGRWD 180 QQYVIQLTSM 190 FKDVPLTAEE 200 VEFVVEKALS 210 MFSKMNLQEI 220 PPLVYQLLVL 230 SSKGSRKSVL 240 EGIIAFFSAL 250 DKQHNEEQSG 260 DELLDVVTVP 270 SGELRHVEGT 280 IILHIVFAIK 290 LDYELGRELV 300 KHLKVGQQGD 310 SNNNLSPFSI 320 ALLLSVTRIQ 330 RFQDQVLDLL 340 KTSVVKSFKD 350 LQLLQGSKFL 360 QNLVPHRSYV 370 STMILEVVKN 380 SVHSWDHVTQ 390 GLVELGFILM 400 DSYGPKKVLD 410 GKTIETSPSL 420 SRMPNQHACK 430 LGANILLETF 440 KIHEMIRQEI 450 LEQVLNRVVT 460 RASSPISHFL 470 DLLSNIVMYA 480 PLVLQSCSSK 490 VTEAFDYLSF 500 LPLQTVQRLL 510 KAVQPLLKVS 520 MSMRDCLILV 530 LRKAMFANQL 540 DARKSAVAGF 550 LLLLKNFKVL 560 GSLSSSQCSQ 570 SLSVSQVHVD 580 VHSHYNSVAN 590 ETFCLEIMDS 600 LRRCLSQQAD 610 VRLMLYEGFY 620 DVLRRNSQLA 630 NSVMQTLLSQ 640 LKQFYEPKPD 650 LLPPLKLEAC 660 ILTQGDKISL 670 QEPLDYLLCC 680 IQHCLAWYKN 690 TVIPLQQGEE 700 EEEEEEAFYE 710 DLDDILESIT 720 NRMIKSELED 730 FELDKSADFS 740 QSTSIGIKNN 750 ICAFLVMGVC 760 EVLIEYNFSI 770 SSFSKNRFED 780 ILSLFMCYKK 790 LSDILNEKAG 800 KAKTKMANKT 810 SDSLLSMKFV 820 SSLLTALFRD 830 SIQSHQESLS 840 VLRSSNEFMR 850 YAVNVALQKV 860 QQLKETGHVS 870 GPDGQNPEKI 880 FQNLCDITRV 890 LLWRYTSIPT 900 SVEESGKKEK 910 GKSISLLCLE 920 GLQKIFSAVQ 930 QFYQPKIQQF 940 LRALDVTDKE 950 GEEREDADVS 960 VTQRTAFQIR 970 QFQRSLLNLL 980 SSQEEDFNSK 990 EALLLVTVLT 1000 SLSKLLEPSS 1010 PQFVQMLSWT 1020 SKICKENSRE 1030 DALFCKSLMN 1040 LLFSLHVSYK 1050 SPVILLRDLS 1060 QDIHGHLGDI 1070 DQDVEVEKTN 1080 HFAIVNLRTA 1090 APTVCLLVLS 1100 QAEKVLEEVD 1110 WLITKLKGQV 1120 SQETLSEEAS 1130 SQATLPNQPV 1140 EKAIIMQLGT 1150 LLTFFHELVQ 1160 TALPSGSCVD 1170 TLLKDLCKMY 1180 TTLTALVRYY 1190 LQVCQSSGGI 1200 PKNMEKLVKL 1210 SGSHLTPLCY 1220 SFISYVQNKS 1230 KSLNYTGEKK 1240 EKPAAVATAM 1250 ARVLRETKPI 1260 PNLIFAIEQY 1270 EKFLIHLSKK 1280 SKVNLMQHMK 1290 LSTSRDFKIK 1300 GNILDMVLRE 1310 DGEDENEEGT 1320 ASEHGGQNKE PAKKKRKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0070182 DNA polymerase binding
Biological Process GO:0036297 interstrand cross-link repair
Biological Process GO:0031398 positive regulation of protein ubiquitination

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.