Search Results

Overview

Uniprot IDQ9NVR2
Protein NameIntegrator complex subunit 10
Gene NameINTS10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
234 SDLMSPSKRSSQKYI
239 PSKRSSQKYIIEGLT
659 PNQGMLIKHHTVTRG
669 TVTRGITKGVKEDFR

Function

Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:32647223). Within the integrator complex, INTS10 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)

Protein Sequence

10 MSAQGDCEFL 20 VQRARELVPQ 30 DLWAAKAWLI 40 TARSLYPADF 50 NIQYEMYTIE 60 RNAERTATAG 70 RLLYDMFVNF 80 PDQPVVWREI 90 SIITSALRND 100 SQDKQTQFLR 110 SLFETLPGRV 120 QCEMLLKVTE 130 QCFNTLERSE 140 MLLLLLRRFP 150 ETVVQHGVGL 160 GEALLEAETI 170 EEQESPVNCF 180 RKLFVCDVLP 190 LIINNHDVRL 200 PANLLYKYLN 210 KAAEFYINYV 220 TRSTQIENQH 230 QGAQDTSDLM 240 SPSKRSSQKY 250 IIEGLTEKSS 260 QIVDPWERLF 270 KILNVVGMRC 280 EWQMDKGRRS 290 YGDILHRMKD 300 LCRYMNNFDS 310 EAHAKYKNQV 320 VYSTMLVFFK 330 NAFQYVNSIQ 340 PSLFQGPNAP 350 SQVPLVLLED 360 VSNVYGDVEI 370 DRNKHIHKKR 380 KLAEGREKTM 390 SSDDEDCSAK 400 GRNRHIVVNK 410 AELANSTEVL 420 ESFKLARESW 430 ELLYSLEFLD 440 KEFTRICLAW 450 KTDTWLWLRI 460 FLTDMIIYQG 470 QYKKAIASLH 480 HLAALQGSIS 490 QPQITGQGTL 500 EHQRALIQLA 510 TCHFALGEYR 520 MTCEKVLDLM 530 CYMVLPIQDG 540 GKSQEEPSKV 550 KPKFRKGSDL 560 KLLPCTSKAI 570 MPYCLHLMLA 580 CFKLRAFTDN 590 RDDMALGHVI 600 VLLQQEWPRG 610 ENLFLKAVNK 620 ICQQGNFQYE 630 NFFNYVTNID 640 MLEEFAYLRT 650 QEGGKIHLEL 660 LPNQGMLIKH 670 HTVTRGITKG 680 VKEDFRLAME 690 RQVSRCGENL 700 MVVLHRFCIN 710 EKILLLQTLT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0160232 INTAC complex
Cellular Component GO:0032039 integrator complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0034243 regulation of transcription elongation by RNA polymerase II
Biological Process GO:0160240 RNA polymerase II transcription initiation surveillance
Biological Process GO:0016180 snRNA processing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.