Search Results
Overview
| Uniprot ID | Q9NVS9 |
|---|---|
| Protein Name | Pyridoxine-5'-phosphate oxidase |
| Gene Name | PNPO |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | SARMLLLKGFGKDGF |
| 148 | RVEGPVKKLPEEEAE |
| 163 | CYFHSRPKSSQIGAV |
| 187 | DREYLRKKNEELEQL |
Function
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
Protein Sequence
10
MTCWLRGVTA
20
TFGRPAEWPG
30
YLSHLCGRSA
40
AMDLGPMRKS
50
YRGDREAFEE
60
THLTSLDPVK
70
QFAAWFEEAV
80
QCPDIGEANA
90
MCLATCTRDG
100
KPSARMLLLK
110
GFGKDGFRFF
120
TNFESRKGKE
130
LDSNPFASLV
140
FYWEPLNRQV
150
RVEGPVKKLP
160
EEEAECYFHS
170
RPKSSQIGAV
180
VSHQSSVIPD
190
REYLRKKNEE
200
LEQLYQDQEV
210
PKPKSWGGYV
220
LYPQVMEFWQ
230
GQTNRLHDRI
240
VFRRGLPTGD
250
SPLGPMTHRG
260
EEDWLYERLA
P
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0042823 | pyridoxal phosphate biosynthetic process |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0010181 | FMN binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Molecular Function | GO:0004733 | pyridoxamine phosphate oxidase activity |
| Biological Process | GO:0008615 | pyridoxine biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.