Search Results

Overview

Uniprot ID	Q9NVT9
Protein Name	Armadillo repeat-containing protein 1
Gene Name	ARMC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
130	EMNSRRRKAQFFLGT

Function

In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility

Protein Sequence

10 MNSSTSTMSE 20 EPDALSVVNQ 30 LRDLAADPLN 40 RRAIVQDQGC 50 LPGLILFMDH 60 PNPPVVHSAL 70 LALRYLAECR 80 ANREKMKGEL 90 GMMLSLQNVI 100 QKTTTPGETK 110 LLASEIYDIL 120 QSSNMADGDS 130 FNEMNSRRRK 140 AQFFLGTTNK 150 RAKTVVLHID 160 GLDDTSRRNL 170 CEEALLKIKG 180 VISFTFQMAV 190 QRCVVRIRSD 200 LKAEALASAI 210 ASTKVMKAQQ 220 VVKSESGEEM 230 LVPFQDTPVE 240 VEQNTELPDY 250 LPEDESPTKE 260 QDKAVSRVGS 270 HPEGGASWLS 280 TAANFLSRSF YW

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0048312	intracellular distribution of mitochondria

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.