Search Results

Overview

Uniprot IDQ9NVU7
Protein NameProtein SDA1 homolog
Gene NameSDAD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
254 LVQYATGKKSSKNKK
255 VQYATGKKSSKNKKK
541 PMEERKAKAAAISTS
558 LTQEDFQKIRMAQMR
574 ELDAAPGKSQKRKYI
621 LATAMAGKTDRKEFV

Function

Required for 60S pre-ribosomal subunits export to the cytoplasm

Protein Sequence

10 MSNRNNNKLP 20 SNLPQLQNLI 30 KRDPPAYIEE 40 FLQQYNHYKS 50 NVEIFKLQPN 60 KPSKELAELV 70 MFMAQISHCY 80 PEYLSNFPQE 90 VKDLLSCNHT 100 VLDPDLRMTF 110 CKALILLRNK 120 NLINPSSLLE 130 LFFELFRCHD 140 KLLRKTLYTH 150 IVTDIKNINA 160 KHKNNKVNVV 170 LQNFMYTMLR 180 DSNATAAKMS 190 LDVMIELYRR 200 NIWNDAKTVN 210 VITTACFSKV 220 TKILVAALTF 230 FLGKDEDEKQ 240 DSDSESEDDG 250 PTARDLLVQY 260 ATGKKSSKNK 270 KKLEKAMKVL 280 KKQKKKKKPE 290 VFNFSAIHLI 300 HDPQDFAEKL 310 LKQLECCKER 320 FEVKMMLMNL 330 ISRLVGIHEL 340 FLFNFYPFLQ 350 RFLQPHQREV 360 TKILLFAAQA 370 SHHLVPPEII 380 QSLLMTVANN 390 FVTDKNSGEV 400 MTVGINAIKE 410 ITARCPLAMT 420 EELLQDLAQY 430 KTHKDKNVMM 440 SARTLIHLFR 450 TLNPQMLQKK 460 FRGKPTEASI 470 EARVQEYGEL 480 DAKDYIPGAE 490 VLEVEKEENA 500 ENDEDGWEST 510 SLSEEEDADG 520 EWIDVQHSSD 530 EEQQEISKKL 540 NSMPMEERKA 550 KAAAISTSRV 560 LTQEDFQKIR 570 MAQMRKELDA 580 APGKSQKRKY 590 IEIDSDEEPR 600 GELLSLRDIE 610 RLHKKPKSDK 620 ETRLATAMAG 630 KTDRKEFVRK 640 KTKTNPFSSS 650 TNKEKKKQKN 660 FMMMRYSQNV 670 RSKNKRSFRE 680 KQLALRDALL KKRKRMK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Biological Process GO:0015031 protein transport
Biological Process GO:0042273 ribosomal large subunit biogenesis
Biological Process GO:0000055 ribosomal large subunit export from nucleus

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.