Search Results

Overview

Uniprot IDQ9NW13
Protein NameRNA-binding protein 28
Gene NameRBM28
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
196 AVAKDKYKDTQSVSA
269 TKPVQIQKRAVKRPA
42 VVTEKGSKACRGFGY
425 VTRDEAAKLQTTKVK
641 VPPEQKRKAGSTSWT
669 PDGKKRRKVLALPSH
740 LVEQYKQKLLGPSKG
746 QKLLGPSKGAPLAKR

Function

Nucleolar component of the spliceosomal ribonucleoprotein complexes

Protein Sequence

10 MAGLTLFVGR 20 LPPSARSEQL 30 EELFSQVGPV 40 KQCFVVTEKG 50 SKACRGFGYV 60 TFSMLEDVQR 70 ALKEITTFEG 80 CKINVTVAKK 90 KLRNKTKEKG 100 KNENSECPKK 110 EPKAKKAKVA 120 DKKARLIIRN 130 LSFKCSEDDL 140 KTVFAQFGAV 150 LEVNIPRKPD 160 GKMRGFGFVQ 170 FKNLLEAGKA 180 LKGMNMKEIK 190 GRTVAVDWAV 200 AKDKYKDTQS 210 VSAIGEEKSH 220 ESKHQESVKK 230 KGREEEDMEE 240 EENDDDDDDD 250 DEEDGVFDDE 260 DEEEENIESK 270 VTKPVQIQKR 280 AVKRPAPAKS 290 SDHSEEDSDL 300 EESDSIDDGE 310 ELAQSDTSTE 320 EQEDKAVQVS 330 NKKKRKLPSD 340 VNEGKTVFIR 350 NLSFDSEEEE 360 LGELLQQFGE 370 LKYVRIVLHP 380 DTEHSKGCAF 390 AQFMTQEAAQ 400 KCLLAASPEN 410 EAGGLKLDGR 420 QLKVDLAVTR 430 DEAAKLQTTK 440 VKKPTGTRNL 450 YLAREGLIRA 460 GTKAAEGVSA 470 ADMAKRERFE 480 LLKHQKLKDQ 490 NIFVSRTRLC 500 LHNLPKAVDD 510 KQLRKLLLSA 520 TSGEKGVRIK 530 ECRVMRDLKG 540 VHGNMKGQSL 550 GYAFAEFQEH 560 EHALKALRLI 570 NNNPEIFGPL 580 KRPIVEFSLE 590 DRRKLKMKEL 600 RIQRSLQKMR 610 SKPATGEPQK 620 GQPEPAKDQQ 630 QKAAQHHTEE 640 QSKVPPEQKR 650 KAGSTSWTGF 660 QTKAEVEQVE 670 LPDGKKRRKV 680 LALPSHRGPK 690 IRLRDKGKVK 700 PVHPKKPKPQ 710 INQWKQEKQQ 720 LSSEQVSRKK 730 AKGNKTETRF 740 NQLVEQYKQK 750 LLGPSKGAPL AKRSKWFDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.