Search Results

Overview

Uniprot IDQ9NW82
Protein NameWD repeat-containing protein 70
Gene NameWDR70
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
318 WEVENPKKQKSVFKP
320 VENPKKQKSVFKPRT
324 KKQKSVFKPRTMQGK
436 CCFSPDDKLIVTGTS
509 NKSQRGAKLCVVKTQ
514 GAKLCVVKTQRKAKQ
626 WVSPAYSKTQPKTMF

Function

No function data available.

Protein Sequence

10 MERSGPSEVT 20 GSDASGPDPQ 30 LAVTMGFTGF 40 GKKARTFDLE 50 AMFEQTRRTA 60 VERSRKTLEA 70 REKEEEMNRE 80 KELRRQNEDI 90 EPTSSRSNVV 100 RDCSKSSSRD 110 TSSSESEQSS 120 DSSDDELIGP 130 PLPPKMVGKP 140 VNFMEEDILG 150 PLPPPLNEEE 160 EEAEEEEEEE 170 EEEENPVHKI 180 PDSHEITLKH 190 GTKTVSALGL 200 DPSGARLVTG 210 GYDYDVKFWD 220 FAGMDASFKA 230 FRSLQPCECH 240 QIKSLQYSNT 250 GDMILVVSGS 260 SQAKVIDRDG 270 FEVMECIKGD 280 QYIVDMANTK 290 GHTAMLHTGS 300 WHPKIKGEFM 310 TCSNDATVRT 320 WEVENPKKQK 330 SVFKPRTMQG 340 KKVIPTTCTY 350 SRDGNLIAAA 360 CQNGSIQIWD 370 RNLTVHPKFH 380 YKQAHDSGTD 390 TSCVTFSYDG 400 NVLASRGGDD 410 SLKLWDIRQF 420 NKPLFSASGL 430 PTMFPMTDCC 440 FSPDDKLIVT 450 GTSIQRGCGS 460 GKLVFFERRT 470 FQRVYEIDIT 480 DASVVRCLWH 490 PKLNQIMVGT 500 GNGLAKVYYD 510 PNKSQRGAKL 520 CVVKTQRKAK 530 QAETLTQDYI 540 ITPHALPMFR 550 EPRQRSTRKQ 560 LEKDRLDPLK 570 SHKPEPPVAG 580 PGRGGRVGTH 590 GGTLSSYIVK 600 NIALDKTDDS 610 NPREAILRHA 620 KAAEDSPYWV 630 SPAYSKTQPK 640 TMFAQVESDD 650 EEAKNEPEWK KRKI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0035861 site of double-strand break
Molecular Function GO:0019899 enzyme binding
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.