Search Results

Overview

Uniprot ID	Q9NWB6
Protein Name	Arginine and glutamate-rich protein 1
Gene Name	ARGLU1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
253	RQQKEEQKIILGKGK
258	EQKIILGKGKSRPKL
264	GKGKSRPKLSFSLKT

Function

Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing (PubMed:30698747). General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1 (PubMed:30698747). Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (PubMed:30698747). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (PubMed:27899669, PubMed:36533631). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (PubMed:36533631). May also indirectly modulate alternative splicing (PubMed:30698747). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization (By similarity). Regulates splicing of genes involved in neurogenesis and chromatin organization (By similarity). Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes (PubMed:21454576). Can act in cooperation with MED1 (PubMed:21454576)

Protein Sequence

10 MGRSRSRSSS 20 RSKHTKSSKH 30 NKKRSRSRSR 40 SRDKERVRKR 50 SKSRESKRNR 60 RRESRSRSRS 70 TNTAVSRRER 80 DRERASSPPD 90 RIDIFGRTVS 100 KRSSLDEKQK 110 REEEEKKAEF 120 ERQRKIRQQE 130 IEEKLIEEET 140 ARRVEELVAK 150 RVEEELEKRK 160 DEIEREVLRR 170 VEEAKRIMEK 180 QLLEELERQR 190 QAELAAQKAR 200 EEEERAKREE 210 LERILEENNR 220 KIAEAQAKLA 230 EEQLRIVEEQ 240 RKIHEERMKL 250 EQERQRQQKE 260 EQKIILGKGK 270 SRPKLSFSLK TQD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0036002	pre-mRNA binding
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
Biological Process	GO:0008380	RNA splicing

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.