Search Results

Overview

Uniprot IDQ9NWH9
Protein NameSAFB-like transcription modulator
Gene NameSLTM
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1024 RGSGSGFKPFKGGPP
1027 GSGFKPFKGGPPRRF
31 DLRVIDLKSELKRRN
35 IDLKSELKRRNLDIT
552 EKKRISSKSPGHMVI
578 SRRGRYEKIHGRSKE
611 ILPFEKMKEQRLREH
77 VSTDTPNKKPTKGKG
803 FVGQSEGKKARPTAR
804 VGQSEGKKARPTARR
821 PSFERYPKNFSDSRR
83 NKKPTKGKGKKHEAD
86 PTKGKGKKHEADELS
884 PSRPTSWKSEGSMST
966 RDTSGPRKEWHGPPS

Function

When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis

Protein Sequence

10 MAAATGAVAA 20 SAASGQAEGK 30 KITDLRVIDL 40 KSELKRRNLD 50 ITGVKTVLIS 60 RLKQAIEEEG 70 GDPDNIELTV 80 STDTPNKKPT 90 KGKGKKHEAD 100 ELSGDASVED 110 DAFIKDCELE 120 NQEAHEQDGN 130 DELKDSEEFG 140 ENEEENVHSK 150 ELLSAEENKR 160 AHELIEAEGI 170 EDIEKEDIES 180 QEIEAQEGED 190 DTFLTAQDGE 200 EEENEKDIAG 210 SGDGTQEVSK 220 PLPSEGSLAE 230 ADHTAHEEME 240 AHTTVKEAED 250 DNISVTIQAE 260 DAITLDFDGD 270 DLLETGKNVK 280 ITDSEASKPK 290 DGQDAIAQSP 300 EKESKDYEMN 310 ANHKDGKKED 320 CVKGDPVEKE 330 ARESSKKAES 340 GDKEKDTLKK 350 GPSSTGASGQ 360 AKSSSKESKD 370 SKTSSKDDKG 380 STSSTSGSSG 390 SSTKNIWVSG 400 LSSNTKAADL 410 KNLFGKYGKV 420 LSAKVVTNAR 430 SPGAKCYGIV 440 TMSSSTEVSR 450 CIAHLHRTEL 460 HGQLISVEKV 470 KGDPSKKEMK 480 KENDEKSSSR 490 SSGDKKNTSD 500 RSSKTQASVK 510 KEEKRSSEKS 520 EKKESKDTKK 530 IEGKDEKNDN 540 GASGQTSESI 550 KKSEEKKRIS 560 SKSPGHMVIL 570 DQTKGDHCRP 580 SRRGRYEKIH 590 GRSKEKERAS 600 LDKKRDKDYR 610 RKEILPFEKM 620 KEQRLREHLV 630 RFERLRRAME 640 LRRRREIAER 650 ERRERERIRI 660 IREREERERL 670 QRERERLEIE 680 RQKLERERME 690 RERLERERIR 700 IEQERRKEAE 710 RIAREREELR 720 RQQQQLRYEQ 730 EKRNSLKRPR 740 DVDHRRDDPY 750 WSENKKLSLD 760 TDARFGHGSD 770 YSRQQNRFND 780 FDHRERGRFP 790 ESSAVQSSSF 800 ERRDRFVGQS 810 EGKKARPTAR 820 REDPSFERYP 830 KNFSDSRRNE 840 PPPPRNELRE 850 SDRREVRGER 860 DERRTVIIHD 870 RPDITHPRHP 880 REAGPNPSRP 890 TSWKSEGSMS 900 TDKRETRVER 910 PERSGREVSG 920 HSVRGAPPGN 930 RSSASGYGSR 940 EGDRGVITDR 950 GGGSQHYPEE 960 RHVVERHGRD 970 TSGPRKEWHG 980 PPSQGPSYHD 990 TRRMGDGRAG 1000 AGMITQHSSN 1010 ASPINRIVQI 1020 SGNSMPRGSG 1030 SGFKPFKGGP PRRF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.