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Overview

Uniprot ID	Q9NWT1
Protein Name	p21-activated protein kinase-interacting protein 1
Gene Name	PAK1IP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
363	GDSKKATKESGLIST
371	ESGLISTKKRKMVEM
372	SGLISTKKRKMVEML
374	LISTKKRKMVEMLEK

Function

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868)

Protein Sequence

10 MELVAGCYEQ 20 VLFGFAVHPE 30 PEACGDHEQW 40 TLVADFTHHA 50 HTASLSAVAV 60 NSRFVVTGSK 70 DETIHIYDMK 80 KKIEHGALVH 90 HSGTITCLKF 100 YGNRHLISGA 110 EDGLICIWDA 120 KKWECLKSIK 130 AHKGQVTFLS 140 IHPSGKLALS 150 VGTDKTLRTW 160 NLVEGRSAFI 170 KNIKQNAHIV 180 EWSPRGEQYV 190 VIIQNKIDIY 200 QLDTASISGT 210 ITNEKRISSV 220 KFLSESVLAV 230 AGDEEVIRFF 240 DCDSLVCLCE 250 FKAHENRVKD 260 MFSFEIPEHH 270 VIVSASSDGF 280 IKMWKLKQDK 290 KVPPSLLCEI 300 NTNARLTCLG 310 VWLDKVADMK 320 ESLPPAAEPS 330 PVSKEQSKIG 340 KKEPGDTVHK 350 EEKRSKPNTK 360 KRGLTGDSKK 370 ATKESGLIST 380 KKRKMVEMLE 390 KKRKKKKIKT MQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Molecular Function	GO:0004860	protein kinase inhibitor activity
Biological Process	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process	GO:0009968	negative regulation of signal transduction
Biological Process	GO:1901796	regulation of signal transduction by p53 class mediator
Biological Process	GO:0042273	ribosomal large subunit biogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.