Search Results
Overview
| Uniprot ID | Q9NWU1 |
|---|---|
| Protein Name | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial |
| Gene Name | OXSM |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | NEQNFVSKSDIKSMS |
Function
May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function
Protein Sequence
10
MSNCLQNFLK
20
ITSTRLLCSR
30
LCQQLRSKRK
40
FFGTVPISRL
50
HRRVVITGIG
60
LVTPLGVGTH
70
LVWDRLIGGE
80
SGIVSLVGEE
90
YKSIPCSVAA
100
YVPRGSDEGQ
110
FNEQNFVSKS
120
DIKSMSSPTI
130
MAIGAAELAM
140
KDSGWHPQSE
150
ADQVATGVAI
160
GMGMIPLEVV
170
SETALNFQTK
180
GYNKVSPFFV
190
PKILVNMAAG
200
QVSIRYKLKG
210
PNHAVSTACT
220
TGAHAVGDSF
230
RFIAHGDADV
240
MVAGGTDSCI
250
SPLSLAGFSR
260
ARALSTNSDP
270
KLACRPFHPK
280
RDGFVMGEGA
290
AVLVLEEYEH
300
AVQRRARIYA
310
EVLGYGLSGD
320
AGHITAPDPE
330
GEGALRCMAA
340
ALKDAGVQPE
350
EISYINAHAT
360
STPLGDAAEN
370
KAIKHLFKDH
380
AYALAVSSTK
390
GATGHLLGAA
400
GAVEAAFTTL
410
ACYYQKLPPT
420
LNLDCSEPEF
430
DLNYVPLKAQ
440
EWKTEKRFIG
450
LTNSFGFGGT
NATLCIAGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0051792 | medium-chain fatty acid biosynthetic process |
| Biological Process | GO:0051790 | short-chain fatty acid biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.