Search Results
Overview
| Uniprot ID | Q9NX08 |
|---|---|
| Protein Name | COMM domain-containing protein 8 |
| Gene Name | COMMD8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | KLALSSDKIAALRMP |
Function
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966)
Protein Sequence
10
MEPEEGTPLW
20
RLQKLPAELG
30
PQLLHKIIDG
40
ICGRAYPVYQ
50
DYHTVWESEE
60
WMHVLEDIAK
70
FFKAIVGKNL
80
PDEEIFQQLN
90
QLNSLHQETI
100
MKCVKSRKDE
110
IKQALSREIV
120
AISSAQLQDF
130
DWQVKLALSS
140
DKIAALRMPL
150
LSLHLDVKEN
160
GEVKPYSIEM
170
SREELQNLIQ
180
SLEAANKVVL
QLK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0051059 | NF-kappaB binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.