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Overview

Uniprot IDQ9NX24
Protein NameH/ACA ribonucleoprotein complex subunit 2
Gene NameNHP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
121 LGAAAGSKRPTCVIM
49 RLTRKLYKCIKKAVK
5 ***MTKIKADPDGPE
69 RGVKEVQKFVNKGEK

Function

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme

Protein Sequence

10 MTKIKADPDG 20 PEAQAEACSG 30 ERTYQELLVN 40 QNPIAQPLAS 50 RRLTRKLYKC 60 IKKAVKQKQI 70 RRGVKEVQKF 80 VNKGEKGIMV 90 LAGDTLPIEV 100 YCHLPVMCED 110 RNLPYVYIPS 120 KTDLGAAAGS 130 KRPTCVIMVK 140 PHEEYQEAYD 150 ECLEEVQSLP LPL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072589 box H/ACA scaRNP complex
Cellular Component GO:0031429 box H/ACA snoRNP complex
Cellular Component GO:0090661 box H/ACA telomerase RNP complex
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005732 sno(s)RNA-containing ribonucleoprotein complex
Cellular Component GO:0005697 telomerase holoenzyme complex
Molecular Function GO:0034513 box H/ACA snoRNA binding
Molecular Function GO:0003730 mRNA 3'-UTR binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0070034 telomerase RNA binding
Molecular Function GO:0034511 U3 snoRNA binding
Biological Process GO:0031118 rRNA pseudouridine synthesis
Biological Process GO:0000454 snoRNA guided rRNA pseudouridine synthesis
Biological Process GO:0031120 snRNA pseudouridine synthesis
Biological Process GO:0090671 telomerase RNA localization to Cajal body
Biological Process GO:0007004 telomere maintenance via telomerase

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.