Search Results

Overview

Uniprot ID	Q9NX40
Protein Name	OCIA domain-containing protein 1
Gene Name	OCIAD1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
195	LEESPKRKNITYEEL

Function

Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946)

Protein Sequence

10 MNGRADFREP 20 NAEVPRPIPH 30 IGPDYIPTEE 40 ERRVFAECND 50 ESFWFRSVPL 60 AATSMLITQG 70 LISKGILSSH 80 PKYGSIPKLI 90 LACIMGYFAG 100 KLSYVKTCQE 110 KFKKLENSPL 120 GEALRSGQAR 130 RSSPPGHYYQ 140 KSKYDSSVSG 150 QSSFVTSPAA 160 DNIEMLPHYE 170 PIPFSSSMNE 180 SAPTGITDHI 190 VQGPDPNLEE 200 SPKRKNITYE 210 ELRNKNRESY 220 EVSLTQKTDP 230 SVRPMHERVP 240 KKEVKVNKYG DTWDE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005768	endosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005739	mitochondrion
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0061484	hematopoietic stem cell homeostasis
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT
Biological Process	GO:2000736	regulation of stem cell differentiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.