Search Results

Overview

Uniprot IDQ9NX63
Protein NameMICOS complex subunit MIC19
Gene NameCHCHD3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
136 EKDRVLKKQDAFYKE
173 AAEEVEAKFKRYESH
203 ENTHQTLKCSALATQ
76 ELALEQAKKESEDQK

Function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091)

Protein Sequence

10 MGGTTSTRRV 20 TFEADENENI 30 TVVKGIRLSE 40 NVIDRMKESS 50 PSGSKSQRYS 60 GAYGASVSDE 70 ELKRRVAEEL 80 ALEQAKKESE 90 DQKRLKQAKE 100 LDRERAAANE 110 QLTRAILRER 120 ICSEEERAKA 130 KHLARQLEEK 140 DRVLKKQDAF 150 YKEQLARLEE 160 RSSEFYRVTT 170 EQYQKAAEEV 180 EAKFKRYESH 190 PVCADLQAKI 200 LQCYRENTHQ 210 TLKCSALATQ 220 YMHCVNHAKQ SMLEKGG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0140275 MIB complex
Cellular Component GO:0061617 MICOS complex
Cellular Component GO:0044284 mitochondrial crista junction
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0001401 SAM complex
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0019902 phosphatase binding
Biological Process GO:0042407 cristae formation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0007007 inner mitochondrial membrane organization
Biological Process GO:0008053 mitochondrial fusion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.