Search Results

Overview

Uniprot IDQ9NXF1
Protein NameTestis-expressed protein 10
Gene NameTEX10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
13 KRQHDFQKVKLKVGK
34 NATPTNFKTKTIHLP
36 TPTNFKTKTIHLPEQ
759 ILQSAISKHLVGLTV

Function

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211)

Protein Sequence

10 MTKKRKRQHD 20 FQKVKLKVGK 30 KKPKLQNATP 40 TNFKTKTIHL 50 PEQLKEDGTL 60 PTNNRKLNIK 70 DLLSQMHHYN 80 AGVKQSALLG 90 LKDLLSQYPF 100 IIDAHLSNIL 110 SEVTAVFTDK 120 DANVRLAAVQ 130 LLQFLAPKIR 140 AEQISPFFPL 150 VSAHLSSAMT 160 HITEGIQEDS 170 LKVLDILLEQ 180 YPALITGRSS 190 ILLKNFVELI 200 SHQQLSKGLI 210 NRDRSQSWIL 220 SVNPNRRLTS 230 QQWRLKVLVR 240 LSKFLQALAD 250 GSSRLRESEG 260 LQEQKENPHA 270 TSNSIFINWK 280 EHANDQQHIQ 290 VYENGGSQPN 300 VSSQFRLRYL 310 VGGLSGVDEG 320 LSSTENLKGF 330 IEIIIPLLIE 340 CWVEAVPPQL 350 ATPVGNGIER 360 EPLQVMQQVL 370 NIISLLWKLS 380 KQQDETHKLE 390 SWLRKNYLID 400 FKHHFMSRFP 410 YVLKEITKHK 420 RKEPNKSIKH 430 CTVLSNNIDH 440 LLLNLTLSDI 450 MVSLANASTL 460 QKDCSWIEMI 470 RKFVTETLED 480 GSRLNSKQLN 490 RLLGVSWRLM 500 QIQPNREDTE 510 TLIKAVYTLY 520 QQRGLILPVR 530 TLLLKFFSKI 540 YQTEELRSCR 550 FRYRSKVLSR 560 WLAGLPLQLA 570 HLGSRNPELS 580 TQLIDIIHTA 590 AARANKELLK 600 SLQATALRIY 610 DPQEGAVVVL 620 PADSQQRLVQ 630 LVYFLPSLPA 640 DLLSRLSRCC 650 IMGRLSSSLA 660 AMLIGILHMR 670 SSFSGWKYSA 680 KDWLMSDVDY 690 FSFLFSTLTG 700 FSKEELTWLQ 710 SLRGVPHVIQ 720 TQLSPVLLYL 730 TDLDQFLHHW 740 DVTEAVFHSL 750 LVIPARSQNF 760 DILQSAISKH 770 LVGLTVIPDS 780 TAGCVFGVIC 790 KLLDHTCVVS 800 ETLLPFLASC 810 CYSLLYFLLT 820 IEKGEAEHLR 830 KRDKLWGVCV 840 SILALLPRVL 850 RLMLQSLRVN 860 RVGPEELPVV 870 GQLLRLLLQH 880 APLRTHMLTN 890 AILVQQIIKN 900 ITTLKSGSVQ 910 EQWLTDLHYC 920 FNVYITGHPQ GPSALATVY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0071339 MLL1 complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.