Search Results

Overview

Uniprot ID	Q9NXH9
Protein Name	tRNA (guanine(26)-N(2))-dimethyltransferase
Gene Name	TRMT1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
570	PRARPGGKAADEAME
602	AQRAARLKTFPCKRF

Function

Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:10982862, PubMed:28784718, PubMed:37204604, PubMed:39786990). tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival (PubMed:28784718)

Protein Sequence

10 MQGSSLWLSL 20 TFRSARVLSR 30 ARFFEWQSPG 40 LPNTAAMENG 50 TGPYGEERPR 60 EVQETTVTEG 70 AAKIAFPSAN 80 EVFYNPVQEF 90 NRDLTCAVIT 100 EFARIQLGAK 110 GIQIKVPGEK 120 DTQKVVVDLS 130 EQEEEKVELK 140 ESENLASGDQ 150 PRTAAVGEIC 160 EEGLHVLEGL 170 AASGLRSIRF 180 ALEVPGLRSV 190 VANDASTRAV 200 DLIRRNVQLN 210 DVAHLVQPSQ 220 ADARMLMYQH 230 QRVSERFDVI 240 DLDPYGSPAT 250 FLDAAVQAVS 260 EGGLLCVTCT 270 DMAVLAGNSG 280 ETCYSKYGAM 290 ALKSRACHEM 300 ALRIVLHSLD 310 LRANCYQRFV 320 VPLLSISADF 330 YVRVFVRVFT 340 GQAKVKASAS 350 KQALVFQCVG 360 CGAFHLQRLG 370 KASGVPSGRA 380 KFSAACGPPV 390 TPECEHCGQR 400 HQLGGPMWAE 410 PIHDLDFVGR 420 VLEAVSANPG 430 RFHTSERIRG 440 VLSVITEELP 450 DVPLYYTLDQ 460 LSSTIHCNTP 470 SLLQLRSALL 480 HADFRVSLSH 490 ACKNAVKTDA 500 PASALWDIMR 510 CWEKECPVKR 520 ERLSETSPAF 530 RILSVEPRLQ 540 ANFTIREDAN 550 PSSRQRGLKR 560 FQANPEANWG 570 PRPRARPGGK 580 AADEAMEERR 590 RLLQNKRKEP 600 PEDVAQRAAR 610 LKTFPCKRFK 620 EGTCQRGDQC 630 CYSHSPPTPR 640 VSADAAPDCP 650 ETSNQTPPGP GAAAGPGID

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0160104	tRNA (guanine(26)-N2)-dimethyltransferase activity
Molecular Function	GO:0000049	tRNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006400	tRNA modification
Biological Process	GO:0002940	tRNA N2-guanine methylation
Biological Process	GO:0008033	tRNA processing

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.