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Overview

Uniprot IDQ9NXR8
Protein NameInhibitor of growth protein 3
Gene NameING3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
167 HIPEKKFKSEALLST

Function

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome

Protein Sequence

10 MLYLEDYLEM 20 IEQLPMDLRD 30 RFTEMREMDL 40 QVQNAMDQLE 50 QRVSEFFMNA 60 KKNKPEWREE 70 QMASIKKDYY 80 KALEDADEKV 90 QLANQIYDLV 100 DRHLRKLDQE 110 LAKFKMELEA 120 DNAGITEILE 130 RRSLELDTPS 140 QPVNNHHAHS 150 HTPVEKRKYN 160 PTSHHTTTDH 170 IPEKKFKSEA 180 LLSTLTSDAS 190 KENTLGCRNN 200 NSTASSNNAY 210 NVNSSQPLGS 220 YNIGSLSSGT 230 GAGAITMAAA 240 QAVQATAQMK 250 EGRRTSSLKA 260 SYEAFKNNDF 270 QLGKEFSMAR 280 ETVGYSSSSA 290 LMTTLTQNAS 300 SSAADSRSGR 310 KSKNNNKSSS 320 QQSSSSSSSS 330 SLSSCSSSST 340 VVQEISQQTT 350 VVPESDSNSQ 360 VDWTYDPNEP 370 RYCICNQVSY 380 GEMVGCDNQD 390 CPIEWFHYGC 400 VGLTEAPKGK 410 WYCPQCTAAM KRRGSRHK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035267 NuA4 histone acetyltransferase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032777 piccolo histone acetyltransferase complex
Cellular Component GO:0000812 Swr1 complex
Molecular Function GO:0140002 histone H3K4me3 reader activity
Molecular Function GO:0043997 histone H4K12 acetyltransferase activity
Molecular Function GO:0046972 histone H4K16 acetyltransferase activity
Molecular Function GO:0043995 histone H4K5 acetyltransferase activity
Molecular Function GO:0043996 histone H4K8 acetyltransferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:1905168 positive regulation of double-strand break repair via homologous recombination
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:2000779 regulation of double-strand break repair

Reference

PMID: N/A