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Overview

Uniprot IDQ9NXV6
Protein NameCDKN2A-interacting protein
Gene NameCDKN2AIP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
124 TRDELVAKVKKRGIS
142 EGVEEPSKKRVIEGK
143 GVEEPSKKRVIEGKN
149 KKRVIEGKNSSAVEQ
423 QSSESSVKFSCKLTN
495 LADLPQNKSSQESIV

Function

Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence

Protein Sequence

10 MAQEVSEYLS 20 QNPRVAAWVE 30 ALRCDGETDK 40 HWRHRRDFLL 50 RNAGDLAPAG 60 GAASASTDEA 70 ADAESGTRNR 80 QLQQLISFSM 90 AWANHVFLGC 100 RYPQKVMDKI 110 LSMAEGIKVT 120 DAPTYTTRDE 130 LVAKVKKRGI 140 SSSNEGVEEP 150 SKKRVIEGKN 160 SSAVEQDHAK 170 TSAKTERASA 180 QQENSSTCIG 190 SAIKSESGNS 200 ARSSGISSQN 210 SSTSDGDRSV 220 SSQSSSSVSS 230 QVTTAGSGKA 240 SEAEAPDKHG 250 SASFVSLLKS 260 SVNSHMTQST 270 DSRQQSGSPK 280 KSALEGSSAS 290 ASQSSSEIEV 300 PLLGSSGSSE 310 VELPLLSSKP 320 SSETASSGLT 330 SKTSSEASVS 340 SSVAKNSSSS 350 GTSLLTPKSS 360 SSTNTSLLTS 370 KSTSQVAASL 380 LASKSSSQTS 390 GSLVSKSTSL 400 ASVSQLASKS 410 SSQTSTSQLP 420 SKSTSQSSES 430 SVKFSCKLTN 440 EDVKQKQPFF 450 NRLYKTVAWK 460 LVAVGGFSPN 470 VNHGELLNAA 480 IEALKATLDV 490 FFVPLKELAD 500 LPQNKSSQES 510 IVCELRCKSV 520 YLGTGCGKSK 530 ENAKAVASRE 540 ALKLFLKKKV 550 VVKICKRKYR 560 GSEIEDLVLL 570 DEESRPVNLP 580 PALKHPQELL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001652 granular component
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0002039 p53 binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006974 DNA damage response
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0009967 positive regulation of signal transduction
Biological Process GO:0031647 regulation of protein stability

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.