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Overview

Uniprot ID	Q9NXX6
Protein Name	Non-structural maintenance of chromosomes element 4 homolog A
Gene Name	NSMCE4A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
238	PRVDRPRKVPVIQEE

Function

Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus

Protein Sequence

10 MSGDSSGRGP 20 EGRGRGRDPH 30 RDRTRSRSRS 40 RSPLSPRSRR 50 GSARERREAP 60 ERPSLEDTEP 70 SDSGDEMMDP 80 ASLEAEADQG 90 LCRQIRHQYR 100 ALINSVQQNR 110 EDILNAGDKL 120 TEVLEEANTL 130 FNEVSRAREA 140 VLDAHFLVLA 150 SDLGKEKAKQ 160 LRSDLSSFDM 170 LRYVETLLTH 180 MGVNPLEAEE 190 LIRDEDSPDF 200 EFIVYDSWKI 210 TGRTAENTFN 220 KTHTFHFLLG 230 SIYGECPVPK 240 PRVDRPRKVP 250 VIQEERAMPA 260 QLRRMEESHQ 270 EATEKEVERI 280 LGLLQTYFRE 290 DPDTPMSFFD 300 FVVDPHSFPR 310 TVENIFHVSF 320 IIRDGFARIR 330 LDQDRLPVIE 340 PVSINEENEG 350 FEHNTQVRNQ 360 GIIALSYRDW 370 EEIVKTFEIS 380 EPVITPSQRQ QKPSA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000781	chromosome, telomeric region
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0030915	Smc5-Smc6 complex
Biological Process	GO:0140588	chromatin looping
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0000724	double-strand break repair via homologous recombination
Biological Process	GO:0016925	protein sumoylation
Biological Process	GO:0032204	regulation of telomere maintenance

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.