Overview
| Uniprot ID | Q9NY27 |
|---|
| Protein Name | Serine/threonine-protein phosphatase 4 regulatory subunit 2 |
|---|
| Gene Name | PPP4R2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 252 |
VKRLRFDKEGEVRET |
Function
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair
Protein Sequence
10
MDVERLQEAL
20
KDFEKRGKKE
30
VCPVLDQFLC
40
HVAKTGETMI
50
QWSQFKGYFI
60
FKLEKVMDDF
70
RTSAPEPRGP
80
PNPNVEYIPF
90
DEMKERILKI
100
VTGFNGIPFT
110
IQRLCELLTD
120
PRRNYTGTDK
130
FLRGVEKNVM
140
VVSCVYPSSE
150
KNNSNSLNRM
160
NGVMFPGNSP
170
SYTERSNING
180
PGTPRPLNRP
190
KVSLSAPMTT
200
NGLPESTDSK
210
EANLQQNEEK
220
NHSDSSTSES
230
EVSSVSPLKN
240
KHPDEDAVEA
250
EGHEVKRLRF
260
DKEGEVRETA
270
SQTTSSEISS
280
VMVGETEASS
290
SSQDKDKDSR
300
CTRQHCTEED
310
EEEDEEEEEE
320
SFMTSREMIP
330
ERKNQEKESD
340
DALTVNEETS
350
EENNQMEESD
360
VSQAEKDLLH
370
SEGSENEGPV
380
SSSSSDCRET
390
EELVGSNSSK
400
TGEILSESSM
410
ENDDEATEVT
DEPMEQD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0030289 |
protein phosphatase 4 complex |
| Molecular Function |
GO:0019888 |
protein phosphatase regulator activity |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0036211 |
protein modification process |
| Biological Process |
GO:2000779 |
regulation of double-strand break repair |
| Biological Process |
GO:0010569 |
regulation of double-strand break repair via homologous recombination |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
PMID: N/A