Search Results

Overview

Uniprot ID	Q9NY33
Protein Name	Dipeptidyl peptidase 3
Gene Name	DPP3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
182	NCTMEDAKLAQDFLD
615	SKIRSVGKPALERFL

Function

Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109)

Protein Sequence

10 MADTQYILPN 20 DIGVSSLDCR 30 EAFRLLSPTE 40 RLYAYHLSRA 50 AWYGGLAVLL 60 QTSPEAPYIY 70 ALLSRLFRAQ 80 DPDQLRQHAL 90 AEGLTEEEYQ 100 AFLVYAAGVY 110 SNMGNYKSFG 120 DTKFVPNLPK 130 EKLERVILGS 140 EAAQQHPEEV 150 RGLWQTCGEL 160 MFSLEPRLRH 170 LGLGKEGITT 180 YFSGNCTMED 190 AKLAQDFLDS 200 QNLSAYNTRL 210 FKEVDGEGKP 220 YYEVRLASVL 230 GSEPSLDSEV 240 TSKLKSYEFR 250 GSPFQVTRGD 260 YAPILQKVVE 270 QLEKAKAYAA 280 NSHQGQMLAQ 290 YIESFTQGSI 300 EAHKRGSRFW 310 IQDKGPIVES 320 YIGFIESYRD 330 PFGSRGEFEG 340 FVAVVNKAMS 350 AKFERLVASA 360 EQLLKELPWP 370 PTFEKDKFLT 380 PDFTSLDVLT 390 FAGSGIPAGI 400 NIPNYDDLRQ 410 TEGFKNVSLG 420 NVLAVAYATQ 430 REKLTFLEED 440 DKDLYILWKG 450 PSFDVQVGLH 460 ELLGHGSGKL 470 FVQDEKGAFN 480 FDQETVINPE 490 TGEQIQSWYR 500 SGETWDSKFS 510 TIASSYEECR 520 AESVGLYLCL 530 HPQVLEIFGF 540 EGADAEDVIY 550 VNWLNMVRAG 560 LLALEFYTPE 570 AFNWRQAHMQ 580 ARFVILRVLL 590 EAGEGLVTIT 600 PTTGSDGRPD 610 ARVRLDRSKI 620 RSVGKPALER 630 FLRRLQVLKS 640 TGDVAGGRAL 650 YEGYATVTDA 660 PPECFLTLRD 670 TVLLRKESRK 680 LIVQPNTRLE 690 GSDVQLLEYE 700 ASAAGLIRSF 710 SERFPEDGPE 720 LEEILTQLAT 730 ADARFWKGPS EAPSGQA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Molecular Function	GO:0004177	aminopeptidase activity
Molecular Function	GO:0008239	dipeptidyl-peptidase activity
Molecular Function	GO:0008235	metalloexopeptidase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006508	proteolysis

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.