Search Results

Overview

Uniprot IDQ9NY74
Protein NameEwing's tumor-associated antigen 1
Gene NameETAA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
196 EELMKLAKQFDKNME

Function

Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720)

Protein Sequence

10 MSRRRKHDDS 20 PSPKKTPHKT 30 VAAEECGSVV 40 EPGRRRLRSA 50 RGSWPCGARE 60 GPPGPVRQRE 70 QPPTAALCSK 80 SNPEERYETP 90 KRALKMDSLS 100 SSFSSPNDPD 110 GQNDIFWDQN 120 SPLTKQLGKG 130 RKKQIYTTDS 140 DEISHIVNRI 150 APQDEKPTTN 160 SMLDMWIGET 170 AIPCTPSVAK 180 GKSRAKISCT 190 KLKTQSQEEE 200 LMKLAKQFDK 210 NMEELDVIQE 220 QNKRNYDFTQ 230 MISETEILSN 240 YKDNIQMWSL 250 HNIVPEIDNA 260 TKKPIKGNTK 270 ISVANNQNSS 280 QKPFDQIAEA 290 AFNAIFDGST 300 QKCSGQLSQE 310 LPEAFWSTSN 320 TTFVKTNALK 330 EEKIITNETL 340 VIEKLSNKTP 350 RSLSSQVDTP 360 IMTKSCVTSC 370 TKEPETSNKY 380 IDAFTTSDFE 390 DDWENLLGSE 400 PFAMQNIDMP 410 ELFPSKTAHV 420 TDQKEICTFN 430 SKTVKNTSRA 440 NTSPDARLGD 450 SKVLQDLSSK 460 TYDRELIDAE 470 YRFSPNSNKS 480 NKLSTGNKMK 490 FENSSNKIVI 500 QDEIQNCIVT 510 SNLTKIKEDI 520 LTNSTEASER 530 KSALNTRYSN 540 EQKNKCILNQ 550 SIKAPVNTDL 560 FGSANLGSKT 570 SVSNPNQTSA 580 SKVGSFFDDW 590 NDPSFANEII 600 KACHQLDNTW 610 EADDVDDDLL 620 YQACDDIERL 630 TQQQDIRKDS 640 KTSESICEIN 650 NNSEHGAKLT 660 QQQDIRKDSK 670 TSESICEINN 680 NSEHGAKNMF 690 AISKQGSNLV 700 QSKHLNPGSI 710 SVQTSLTNSS 720 QIDKPMKMEK 730 GEMYGNSPRF 740 LGATNLTMYS 750 KISNCQINNL 760 HVSYTNTDVP 770 IQVNSSKLVL 780 PGSSSLNVTS 790 DHMNTEITTY 800 KKKLSTNQPC 810 HKTVTDEAQS 820 NLNTTVGFSK 830 FTFTRMKNSQ 840 ILSQFNQNCI 850 TGSMSDTKIT 860 QGVEKKKGVN 870 PLLEEAVGQQ 880 SLVKLSESLK 890 QSSKEEEEKN 900 RKCSPEEIQR 910 KRQEALVRRM 920 AKARASSVNA APTSFL

Gene Ontology

Classification GO ID Description
Molecular Function GO:0043539 protein serine/threonine kinase activator activity
Cellular Component GO:0043596 nuclear replication fork
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006281 DNA repair
Biological Process GO:0044818 mitotic G2/M transition checkpoint
Biological Process GO:0071902 positive regulation of protein serine/threonine kinase activity
Biological Process GO:2000001 regulation of DNA damage checkpoint
Biological Process GO:0031297 replication fork processing

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.