Overview
| Uniprot ID | Q9NY93 |
|---|
| Protein Name | Probable ATP-dependent RNA helicase DDX56 |
|---|
| Gene Name | DDX56 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 337 |
GRGPKGDKASDPEAG |
| 525 |
CRKAKRAKSQNPLRS |
Function
Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization (PubMed:31340999, PubMed:33789112). Plays an essential role in maintaining nucleolar integrity in planarian stem cells (PubMed:33789112). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3 (PubMed:31340999). Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5 (PubMed:31340999). May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity
Protein Sequence
10
MEDSEALGFE
20
HMGLDPRLLQ
30
AVTDLGWSRP
40
TLIQEKAIPL
50
ALEGKDLLAR
60
ARTGSGKTAA
70
YAIPMLQLLL
80
HRKATGPVVE
90
QAVRGLVLVP
100
TKELARQAQS
110
MIQQLATYCA
120
RDVRVANVSA
130
AEDSVSQRAV
140
LMEKPDVVVG
150
TPSRILSHLQ
160
QDSLKLRDSL
170
ELLVVDEADL
180
LFSFGFEEEL
190
KSLLCHLPRI
200
YQAFLMSATF
210
NEDVQALKEL
220
ILHNPVTLKL
230
QESQLPGPDQ
240
LQQFQVVCET
250
EEDKFLLLYA
260
LLKLSLIRGK
270
SLLFVNTLER
280
SYRLRLFLEQ
290
FSIPTCVLNG
300
ELPLRSRCHI
310
ISQFNQGFYD
320
CVIATDAEVL
330
GAPVKGKRRG
340
RGPKGDKASD
350
PEAGVARGID
360
FHHVSAVLNF
370
DLPPTPEAYI
380
HRAGRTARAN
390
NPGIVLTFVL
400
PTEQFHLGKI
410
EELLSGENRG
420
PILLPYQFRM
430
EEIEGFRYRC
440
RDAMRSVTKQ
450
AIREARLKEI
460
KEELLHSEKL
470
KTYFEDNPRD
480
LQLLRHDLPL
490
HPAVVKPHLG
500
HVPDYLVPPA
510
LRGLVRPHKK
520
RKKLSSSCRK
530
AKRAKSQNPL
540
RSFKHKGKKF
RPTAKPS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0140311 |
protein sequestering activity |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0003724 |
RNA helicase activity |
| Molecular Function |
GO:0035613 |
RNA stem-loop binding |
| Biological Process |
GO:0051607 |
defense response to virus |
| Biological Process |
GO:0044830 |
host-mediated perturbation of viral RNA genome replication |
| Biological Process |
GO:0032480 |
negative regulation of type I interferon production |
| Biological Process |
GO:0010976 |
positive regulation of neuron projection development |
| Biological Process |
GO:0006364 |
rRNA processing |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.