Overview
| Uniprot ID | Q9NYB9 |
|---|
| Protein Name | Abl interactor 2 |
|---|
| Gene Name | ABI2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 167 |
KVSTQNMKMGGLPRT |
Function
Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692)
Protein Sequence
10
MAELQMLLEE
20
EIPGGRRALF
30
DSYTNLERVA
40
DYCENNYIQS
50
ADKQRALEET
60
KAYTTQSLAS
70
VAYLINTLAN
80
NVLQMLDIQA
90
SQLRRMESSI
100
NHISQTVDIH
110
KEKVARREIG
120
ILTTNKNTSR
130
THKIIAPANL
140
ERPVRYIRKP
150
IDYTILDDIG
160
HGVKWLLRFK
170
VSTQNMKMGG
180
LPRTTPPTQK
190
PPSPPMSGKG
200
TLGRHSPYRT
210
LEPVRPPVVP
220
NDYVPSPTRN
230
MAPSQQSPVR
240
TASVNQRNRT
250
YSSSGSSGGS
260
HPSSRSSSRE
270
NSGSGSVGVP
280
IAVPTPSPPS
290
VFPAPAGSAG
300
TPPLPATSAS
310
APAPLVPATV
320
PSSTAPNAAA
330
GGAPNLADGF
340
TSPTPPVVSS
350
TPPTGHPVQF
360
YSMNRPASRH
370
TPPTIGGSLP
380
YRRPPSITSQ
390
TSLQNQMNGG
400
PFYSQNPVSD
410
TPPPPPPVEE
420
PVFDESPPPP
430
PPPEDYEEEE
440
AAVVEYSDPY
450
AEEDPPWAPR
460
SYLEKVVAIY
470
DYTKDKEDEL
480
SFQEGAIIYV
490
IKKNDDGWYE
500
GVMNGVTGLF
510
PGNYVESIMH
YSE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0098858 |
actin-based cell projection |
| Cellular Component |
GO:0005912 |
adherens junction |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0032433 |
filopodium tip |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0031209 |
SCAR complex |
| Molecular Function |
GO:0008093 |
cytoskeletal anchor activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0019900 |
kinase binding |
| Molecular Function |
GO:0017124 |
SH3 domain binding |
| Molecular Function |
GO:0035591 |
signaling adaptor activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0008154 |
actin polymerization or depolymerization |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0048858 |
cell projection morphogenesis |
| Biological Process |
GO:0007010 |
cytoskeleton organization |
| Biological Process |
GO:0070309 |
lens fiber cell morphogenesis |
| Biological Process |
GO:0000423 |
mitophagy |
| Biological Process |
GO:0001764 |
neuron migration |
| Biological Process |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
| Biological Process |
GO:2000601 |
positive regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process |
GO:0010592 |
positive regulation of lamellipodium assembly |
| Biological Process |
GO:0016601 |
Rac protein signal transduction |
| Biological Process |
GO:0061001 |
regulation of dendritic spine morphogenesis |
| Biological Process |
GO:0045186 |
zonula adherens assembly |
Reference
[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.