Search Results

Overview

Uniprot ID	Q9NYL9
Protein Name	Tropomodulin-3
Gene Name	TMOD3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
101	KGKIFIPKQKPVQTF
58	RQKNQTSKSTTGPFD
96	YTGEKKGKIFIPKQK

Function

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)

Protein Sequence

10 MALPFRKDLE 20 KYKDLDEDEL 30 LGNLSETELK 40 QLETVLDDLD 50 PENALLPAGF 60 RQKNQTSKST 70 TGPFDREHLL 80 SYLEKEALEH 90 KDREDYVPYT 100 GEKKGKIFIP 110 KQKPVQTFTE 120 EKVSLDPELE 130 EALTSASDTE 140 LCDLAAILGM 150 HNLITNTKFC 160 NIMGSSNGVD 170 QEHFSNVVKG 180 EKILPVFDEP 190 PNPTNVEESL 200 KRTKENDAHL 210 VEVNLNNIKN 220 IPIPTLKDFA 230 KALETNTHVK 240 CFSLAATRSN 250 DPVATAFAEM 260 LKVNKTLKSL 270 NVESNFITGV 280 GILALIDALR 290 DNETLAELKI 300 DNQRQQLGTA 310 VELEMAKMLE 320 ENTNILKFGY 330 QFTQQGPRTR 340 AANAITKNND 350 LVRKRRVEGD HQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0030016	myofibril
Cellular Component	GO:0005865	striated muscle thin filament
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0098641	cadherin binding involved in cell-cell adhesion
Molecular Function	GO:0005523	tropomyosin binding
Biological Process	GO:0007015	actin filament organization
Biological Process	GO:0006936	muscle contraction
Biological Process	GO:0030239	myofibril assembly
Biological Process	GO:0051694	pointed-end actin filament capping

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.