Search Results
Overview
| Uniprot ID | Q9NYS0 |
|---|---|
| Protein Name | NF-kappa-B inhibitor-interacting Ras-like protein 1 |
| Gene Name | NKIRAS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 174 | KLSQPQSKSSFPLPG |
Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB
Protein Sequence
10
MGKGCKVVVC
20
GLLSVGKTAI
30
LEQLLYGNHT
40
IGMEDCETME
50
DVYMASVETD
60
RGVKEQLHLY
70
DTRGLQEGVE
80
LPKHYFSFAD
90
GFVLVYSVNN
100
LESFQRVELL
110
KKEIDKFKDK
120
KEVAIVVLGN
130
KIDLSEQRQV
140
DAEVAQQWAK
150
SEKVRLWEVT
160
VTDRKTLIEP
170
FTLLASKLSQ
180
PQSKSSFPLP
190
GRKNKGNSNS
EN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0032794 | GTPase activating protein binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0032484 | Ral protein signal transduction |
Reference
[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.