Search Results

Overview

Uniprot IDQ9NYU2
Protein NameUDP-glucose:glycoprotein glucosyltransferase 1
Gene NameUGGT1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
157 FFSVHGKKTCESDTL
356 LSQNFPTKARAITKT
362 TKARAITKTAVSSEL
585 VRTGEKVKVEHVVSV
595 HVVSVLEKKYPYVEV

Function

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation

Protein Sequence

10 MGCKGDASGA 20 CAAGALPVTG 30 VCYKMGVLVV 40 LTVLWLFSSV 50 KADSKAITTS 60 LTTKWFSTPL 70 LLEASEFLAE 80 DSQEKFWNFV 90 EASQNIGSSD 100 HDGTDYSYYH 110 AILEAAFQFL 120 SPLQQNLFKF 130 CLSLRSYSAT 140 IQAFQQIAAD 150 EPPPEGCNSF 160 FSVHGKKTCE 170 SDTLEALLLT 180 ASERPKPLLF 190 KGDHRYPSSN 200 PESPVVIFYS 210 EIGSEEFSNF 220 HRQLISKSNA 230 GKINYVFRHY 240 IFNPRKEPVY 250 LSGYGVELAI 260 KSTEYKAKDD 270 TQVKGTEVNT 280 TVIGENDPID 290 EVQGFLFGKL 300 RDLHPDLEGQ 310 LKELRKHLVE 320 STNEMAPLKV 330 WQLQDLSFQT 340 AARILASPVE 350 LALVVMKDLS 360 QNFPTKARAI 370 TKTAVSSELR 380 TEVEENQKYF 390 KGTLGLQPGD 400 SALFINGLHM 410 DLDTQDIFSL 420 FDVLRNEARV 430 MEGLHRLGIE 440 GLSLHNVLKL 450 NIQPSEADYA 460 VDIRSPAISW 470 VNNLEVDSRY 480 NSWPSSLQEL 490 LRPTFPGVIR 500 QIRKNLHNMV 510 FIVDPAHETT 520 AELMNTAEMF 530 LSNHIPLRIG 540 FIFVVNDSED 550 VDGMQDAGVA 560 VLRAYNYVAQ 570 EVDDYHAFQT 580 LTHIYNKVRT 590 GEKVKVEHVV 600 SVLEKKYPYV 610 EVNSILGIDS 620 AYDRNRKEAR 630 GYYEQTGVGP 640 LPVVLFNGMP 650 FEREQLDPDE 660 LETITMHKIL 670 ETTTFFQRAV 680 YLGELPHDQD 690 VVEYIMNQPN 700 VVPRINSRIL 710 TAERDYLDLT 720 ASNNFFVDDY 730 ARFTILDSQG 740 KTAAVANSMN 750 YLTKKGMSSK 760 EIYDDSFIRP 770 VTFWIVGDFD 780 SPSGRQLLYD 790 AIKHQKSSNN 800 VRISMINNPA 810 KEISYENTQI 820 SRAIWAALQT 830 QTSNAAKNFI 840 TKMAKEGAAE 850 ALAAGADIAE 860 FSVGGMDFSL 870 FKEVFESSKM 880 DFILSHAVYC 890 RDVLKLKKGQ 900 RAVISNGRII 910 GPLEDSELFN 920 QDDFHLLENI 930 ILKTSGQKIK 940 SHIQQLRVEE 950 DVASDLVMKV 960 DALLSAQPKG 970 DPRIEYQFFE 980 DRHSAIKLRP 990 KEGETYFDVV 1000 AVVDPVTREA 1010 QRLAPLLLVL 1020 AQLINMNLRV 1030 FMNCQSKLSD 1040 MPLKSFYRYV 1050 LEPEISFTSD 1060 NSFAKGPIAK 1070 FLDMPQSPLF 1080 TLNLNTPESW 1090 MVESVRTPYD 1100 LDNIYLEEVD 1110 SVVAAEYELE 1120 YLLLEGHCYD 1130 ITTGQPPRGL 1140 QFTLGTSANP 1150 VIVDTIVMAN 1160 LGYFQLKANP 1170 GAWILRLRKG 1180 RSEDIYRIYS 1190 HDGTDSPPDA 1200 DEVVIVLNNF 1210 KSKIIKVKVQ 1220 KKADMVNEDL 1230 LSDGTSENES 1240 GFWDSFKWGF 1250 TGQKTEEVKQ 1260 DKDDIINIFS 1270 VASGHLYERF 1280 LRIMMLSVLK 1290 NTKTPVKFWF 1300 LKNYLSPTFK 1310 EFIPYMANEY 1320 NFQYELVQYK 1330 WPRWLHQQTE 1340 KQRIIWGYKI 1350 LFLDVLFPLV 1360 VDKFLFVDAD 1370 QIVRTDLKEL 1380 RDFNLDGAPY 1390 GYTPFCDSRR 1400 EMDGYRFWKS 1410 GYWASHLAGR 1420 KYHISALYVV 1430 DLKKFRKIAA 1440 GDRLRGQYQG 1450 LSQDPNSLSN 1460 LDQDLPNNMI 1470 HQVPIKSLPQ 1480 EWLWCETWCD 1490 DASKKRAKTI 1500 DLCNNPMTKE 1510 PKLEAAVRIV 1520 PEWQDYDQEI 1530 KQLQIRFQKE 1540 KETGALYKEK 1550 TKEPSREGPQ KREEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0044322 endoplasmic reticulum quality control compartment
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0051084 'de novo' post-translational protein folding
Biological Process GO:1904380 endoplasmic reticulum mannose trimming
Biological Process GO:0009101 glycoprotein biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.