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Overview

Uniprot IDQ9NYV6
Protein NameRNA polymerase I-specific transcription initiation factor RRN3
Gene NameRRN3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
22 AASSSAVKKLGASRT
23 ASSSAVKKLGASRTG

Function

Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC)

Protein Sequence

10 MAAPLLHTRL 20 PGDAAASSSA 30 VKKLGASRTG 40 ISNMRALEND 50 FFNSPPRKTV 60 RFGGTVTEVL 70 LKYKKGETND 80 FELLKNQLLD 90 PDIKDDQIIN 100 WLLEFRSSIM 110 YLTKDFEQLI 120 SIILRLPWLN 130 RSQTVVEEYL 140 AFLGNLVSAQ 150 TVFLRPCLSM 160 IASHFVPPRV 170 IIKEGDVDVS 180 DSDDEDDNLP 190 ANFDTCHRAL 200 QIIARYVPST 210 PWFLMPILVE 220 KFPFVRKSER 230 TLECYVHNLL 240 RISVYFPTLR 250 HEILELIIEK 260 LLKLDVNASR 270 QGIEDAEETA 280 TQTCGGTDST 290 EGLFNMDEDE 300 ETEHETKAGP 310 ERLDQMVHPV 320 AERLDILMSL 330 VLSYMKDVCY 340 VDGKVDNGKT 350 KDLYRDLINI 360 FDKLLLPTHA 370 SCHVQFFMFY 380 LCSFKLGFAE 390 AFLEHLWKKL 400 QDPSNPAIIR 410 QAAGNYIGSF 420 LARAKFIPLI 430 TVKSCLDLLV 440 NWLHIYLNNQ 450 DSGTKAFCDV 460 ALHGPFYSAC 470 QAVFYTFVFR 480 HKQLLSGNLK 490 EGLQYLQSLN 500 FERIVMSQLN 510 PLKICLPSVV 520 NFFAAITNKY 530 QLVFCYTIIE 540 RNNRQMLPVI 550 RSTAGGDSVQ 560 ICTNPLDTFF 570 PFDPCVLKRS 580 KKFIDPIYQV 590 WEDMSAEELQ 600 EFKKPMKKDI 610 VEDEDDDFLK 620 GEVPQNDTVI 630 GITPSSFDTH 640 FRSPSSSVGS 650 PPVLYMQPSP L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001042 RNA polymerase I core binding
Molecular Function GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
Molecular Function GO:0001181 RNA polymerase I general transcription initiation factor activity
Biological Process GO:0006361 transcription initiation at RNA polymerase I promoter

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.