Search Results

Overview

Uniprot IDQ9NZB2
Protein NameConstitutive coactivator of PPAR-gamma-like protein 1
Gene NameFAM120A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
426 SNIPHEGKHTPLYER
932 SDSSRTSKSQGGVQP

Function

Membrane-associated scaffold protein that participates in multiple cellular processes, including oxidative stress-induced survival signaling, RNA trafficking and translational regulation, and the modulation of membrane signaling through its interaction with RNA-binding proteins and lipid raft-associated domains (PubMed:19015244). Functions as a regulator of activation of several intracellular kinases, including SRC, FAK, and PI3K, following oxidative stress (PubMed:19015244). Promotes RNA splicing and stability of lipogenic enzymes (PubMed:37595559). Mechanistically, recruits the lipogenic transcription factor SREBP1 at active promoters, thereby bridging the newly transcribed lipogenic genes from RNA polymerase II to the SRSF1 and U1-70K-containing RNA-splicing machinery (PubMed:37595559). Associates with key proteins of the NLRP3 inflammasome pathway and subsequently inhibits NLRP3 inflammasome activation (PubMed:40250624). Sequesters a subset of AGO2-bound mRNAs from miRNA-mediated silencing by binding to poly(G)-rich motifs in their 3'-UTR independently of the AGO2 binding site, likely by preventing recruitment of miRISC effectors (By similarity)

Protein Sequence

10 MGVQGFQDYI 20 EKHCPSAVVP 30 VELQKLARGS 40 LVGGGRQRPP 50 QTPLRLLVDA 60 DNCLHRLYGG 70 FYTDWVSGGQ 80 WNHMLGYLAA 90 LAKACFGGNI 100 ELFVFFNGAL 110 EKARLHEWVK 120 RQGNERQTAQ 130 QIVSHVQNKG 140 TPPPKVWFLP 150 PVCMAHCIRL 160 ALIRFHVKVA 170 QSIEDHHQEV 180 IGFCRENGFH 190 GLVAYDSDYA 200 LCNIPYYFSA 210 HALKLSRNGK 220 SLTTSQYLMH 230 EVAKQLDLNP 240 NRFPIFAALL 250 GNHILPDEDL 260 ASFHWSLLGP 270 EHPLASLKVR 280 AHQLVLPPCD 290 VVIKAVADYV 300 RNIQDTSDLD 310 AIAKDVFQHS 320 QSRTDDKVIR 330 FKRAIGYYSA 340 TSKPMSFHPP 350 HYLAARPGPF 360 GMPGMVPPHV 370 PPQMLNIPQT 380 SLQAKPVAPQ 390 VPSPGGAPGQ 400 GPYPYSLSEP 410 APLTLDTSGK 420 NLTEQNSYSN 430 IPHEGKHTPL 440 YERSSPINPA 450 QSGSPNHVDS 460 AYFPGSSTSS 470 SSDNDEGSGG 480 ATNHISGNKI 490 GWEKTGSHSE 500 PQARGDPGDQ 510 TKAEGSSTAS 520 SGSQLAEGKG 530 SQMGTVQPIP 540 CLLSMPTRNH 550 MDITTPPLPP 560 VAPEVLRVAE 570 HRHKKGLMYP 580 YIFHVLTKGE 590 IKIAVSIEDE 600 ANKDLPPAAL 610 LYRPVRQYVY 620 GVLFSLAESR 630 KKTERLAFRK 640 NRLPPEFSPV 650 IIKEWAAYKG 660 KSPQTPELVE 670 ALAFREWTCP 680 NLKRLWLGKA 690 VEDKNRRMRA 700 FLACMRSDTP 710 AMLNPANVPT 720 HLMVLCCVLR 730 YMVQWPGARI 740 LRRQELDAFL 750 AQALSPKLYE 760 PDQLQELKIE 770 NLDPRGIQLS 780 ALFMSGVDMA 790 LFANDACGQP 800 IPWEHCCPWM 810 YFDGKLFQSK 820 LLKASREKTP 830 LIDLCDGQAD 840 QAAKVEKMRQ 850 SVLEGLSFSR 860 QSHTLPFPPP 870 PALPFYPASA 880 YPRHFGPVPP 890 SQGRGRGFAG 900 VCGFGGPYGE 910 TVATGPYRAF 920 RVAAASGHCG 930 AFSGSDSSRT 940 SKSQGGVQPI 950 PSQGGKLEIA 960 GTVVGHWAGS 970 RRGRGGRGPF 980 PLQVVSVGGP 990 ARGRPRGVIS 1000 TPVIRTFGRG 1010 GRYYGRGYKN 1020 QAAIQGRPPY 1030 AASAEEVAKE 1040 LKSKSGESKS 1050 SAMSSDGSLA 1060 ENGVMAEEKP 1070 APQMNGSTGD 1080 ARAPSHSESA 1090 LNNDSKTCNT 1100 NPHLNALSTD 1110 SACRREAALE AAVLNKEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0003723 RNA binding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.