Search Results
Overview
| Uniprot ID | Q9NZC9 |
|---|---|
| Protein Name | SNF2 related chromatin remodeling annealing helicase 1 |
| Gene Name | SMARCAL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 196 | KLEAKTAKASPSGQN |
| 225 | TEGRLQQKSGSSVQK |
| 232 | KSGSSVQKGVNSQKG |
Function
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks
Protein Sequence
10
MSLPLTEEQR
20
KKIEENRQKA
30
LARRAEKLLA
40
EQHQRTSSGT
50
SIAGNPFQAK
60
QGPSQNFPRE
70
SCKPVSHGVI
80
FKQQNLSSSS
90
NADQRPHDSH
100
SFQAKGIWKK
110
PEEMPTACPG
120
HSPRSQMALT
130
GISPPLAQSP
140
PEVPKQQLLS
150
YELGQGHAQA
160
SPEIRFTPFA
170
NPTHKPLAKP
180
KSSQETPAHS
190
SGQPPRDAKL
200
EAKTAKASPS
210
GQNISYIHSS
220
SESVTPRTEG
230
RLQQKSGSSV
240
QKGVNSQKGK
250
CVRNGDRFQV
260
LIGYNAELIA
270
VFKTLPSKNY
280
DPDTKTWNFS
290
MNDYSALMKA
300
AQSLPTVNLQ
310
PLEWAYGSSE
320
SPSTSSEGQA
330
GLPSAPSLSF
340
VKGRCMLISR
350
AYFEADISYS
360
QDLIALFKQM
370
DSRRYDVKTR
380
KWSFLLEEHS
390
KLIAKVRCLP
400
QVQLDPLPTT
410
LTLAFASQLK
420
KTSLSLTPDV
430
PEADLSEVDP
440
KLVSNLMPFQ
450
RAGVNFAIAK
460
GGRLLLADDM
470
GLGKTIQAIC
480
IAAFYRKEWP
490
LLVVVPSSVR
500
FTWEQAFLRW
510
LPSLSPDCIN
520
VVVTGKDRLT
530
AGLINIVSFD
540
LLSKLEKQLK
550
TPFKVVIIDE
560
SHFLKNSRTA
570
RCRAAMPVLK
580
VAKRVILLSG
590
TPAMSRPAEL
600
YTQIIAVKPT
610
FFPQFHAFGL
620
RYCDAKRMPW
630
GWDYSGSSNL
640
GELKLLLEEA
650
VMLRRLKSDV
660
LSQLPAKQRK
670
IVVIAPGRIN
680
ARTRAALDAA
690
AKEMTTKDKT
700
KQQQKDALIL
710
FFNRTAEAKI
720
PSVIEYILDL
730
LESGREKFLV
740
FAHHKVVLDA
750
ITQELERKHV
760
QHIRIDGSTS
770
SAEREDLCQQ
780
FQLSERHAVA
790
VLSITAANMG
800
LTFSSADLVV
810
FAELFWNPGV
820
LIQAEDRVHR
830
IGQTSSVGIH
840
YLVAKGTADD
850
YLWPLIQEKI
860
KVLAEAGLSE
870
TNFSEMTEST
880
DYLYKDPKQQ
890
KIYDLFQKSF
900
EKEGSDMELL
910
EAAESFDPGS
920
ASGTSGSSSQ
930
NMGDTLDESS
940
LTASPQKKRR
950
FEFFDNWDSF
TSPL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043596 | nuclear replication fork |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0036310 | ATP-dependent DNA/DNA annealing activity |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006303 | double-strand break repair via nonhomologous end joining |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0031297 | replication fork processing |
| Biological Process | GO:0090656 | t-circle formation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.