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Overview

Uniprot IDQ9NZI7
Protein NameUpstream-binding protein 1
Gene NameUBP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
47 VLALPIFKQEDSSLP

Function

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box

Protein Sequence

10 MAWVLKMDEV 20 IESGLVHDFD 30 ASLSGIGQEL 40 GAGAYSMSDV 50 LALPIFKQED 60 SSLPLDGETE 70 HPPFQYVMCA 80 ATSPAVKLHD 90 ETLTYLNQGQ 100 SYEIRMLDNR 110 KMGDMPEING 120 KLVKSIIRVV 130 FHDRRLQYTE 140 HQQLEGWKWN 150 RPGDRLLDLD 160 IPMSVGIIDT 170 RTNPSQLNAV 180 EFLWDPAKRT 190 SAFIQVHCIS 200 TEFTPRKHGG 210 EKGVPFRIQV 220 DTFKQNENGE 230 YTDHLHSASC 240 QIKVFKPKGA 250 DRKQKTDREK 260 MEKRTAHEKE 270 KYQPSYDTTI 280 LTEMRLEPII 290 EDAVEHEQKK 300 SSKRTLPADY 310 GDSLAKRGSC 320 SPWPDAPTAY 330 VNNSPSPAPT 340 FTSPQQSTCS 350 VPDSNSSSPN 360 HQGDGASQTS 370 GEQIQPSATI 380 QETQQWLLKN 390 RFSSYTRLFS 400 NFSGADLLKL 410 TKEDLVQICG 420 AADGIRLYNS 430 LKSRSVRPRL 440 TIYVCREQPS 450 STVLQGQQQA 460 ASSASENGSG 470 APYVYHAIYL 480 EEMIASEVAR 490 KLALVFNIPL 500 HQINQVYRQG 510 PTGIHILVSD 520 QMVQNFQDES 530 CFLFSTVKAE 540 SSDGIHIILK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0032897 negative regulation of viral transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.